Table 3

Changes in MRI volumes between baseline and 5-year follow-up

At 5-year follow-up split by disability progressionCohen's dp Value
Yes (n=27)No (n=40)
T2 lesion volume5.88 (10.81)2.76 (7.89)0.33ns
T1 lesion volume3.83 (7.50)1.89 (4.20)0.32ns
Whole brain volume−3.75 (2.21)−1.98 (1.29)0.98**
Grey matter volume−3.00 (3.49)−2.05 (3.12)0.29ns
White matter volume−1.081 (4.45)−1.10 (2.92)0.01ns
Lateral ventricular volume20.03 (23.16)11.03 (16.35)0.45ns
Cortical volume−3.44 (2.89)−1.83 (1.95)0.65**
Total SDGM volume−6.60 (6.70)−2.96 (4.54)0.64*
Subcortical deep grey matter structures
T2 lesion SDGM volume18.35 (401.4)−26.8 (373.5)0.12ns
T1 lesion SDGM volume2.48 (147.4)0.25 (73.9)0.02ns
Caudate−6.05 (6.42)−3.26 (5.53)0.47ns
Putamen−10.56 (11.70)−3.81 (6.50)0.71**
Globus pallidus−6.67 (10.21)−1.74 (6.46)0.58*
Thalamus−5.04 (6.19)−2.73 (4.29)0.43ns
Hippocampus−4.06 (7.49)−2.61 (5.82)0.22ns
Amygdala−5.37 (12.34)−0.38 (7.49)0.49*
Accumbens−15.08 (19.05)−9.11 (12.68)0.36ns
  • Disability progression was measured using the Expanded Disability Status Scale.

  • Lesion volume changes are expressed in absolute change and SDs in millilitres. All brain volume changes are expressed in percentage changes and SDs.

  • The differences between the disability progressing and non-progressing groups were calculated using Student t test and Mann–Whitney rank sum test, as appropriate.

  • **Significant at p<0.01.

  • *Trend at p<0.05.

  • ns, non-significant; SDGM, subcortical deep grey matter.