Table 2

Baseline MRI brain characteristics split by disability progression status at 5-year and 10-year follow-up

5-year follow-up split by disability progressionp Value10-year follow-up split by disability progressionp Value
Yes (n=27) No (n=40)Yes (n=25) No (n=25)
T2 lesion volume19.22 (15.62) [16.18]10.91 (10.82) [7.82]ns16.75 (14.97) [13,15]9.88 (10.53) [7.30]ns
T1 lesion volume7.07 (6.85) [6.85]3.74 (5.23) [2.33]*5.09 (4.87) [3.27]2.89 (4.29) [2.15]ns
Normalised whole brain volume1.46 (0.076) [1.47]1.48 (0.09) [1.46]ns1.46 (0.08) [1.47]1.49 (0.08) [1.49]ns
Normalised grey matter volume0.75 (0.05) [0.75]0.77 (0.06) [0.76]ns0.75 (0.05) [0.75]0.77 (0.06) [0.77]ns
Normalised white matter volume0.71 (0.04) [0.70]0.71 (0.05) [0.71]ns0.71 (0.04) [0.70]0.72 (0.04) [0.72]ns
Normalised lateral ventricular volume0.06 (0.02) [0.05]0.05 (0.02) [0.05]ns0.06 (0.02) [0.05]0.05 (0.02) [0.05]ns
Normalised cortical volume0.57 (0.04) [0.56]0.58 (0.05) [0.58]ns0.57 (0.04) [0.56]0.59 (0.05) [0.59]ns
Normalised total SDGM volume0.04 (0.01) [0.04]0.05 (0.01) [0.05]ns0.04 (0.01) [0.04]0.05 (0.01) [0.05]ns
Subcortical deep grey matter structures
T2 lesion SDGM volume0.25 (0.34) [0.12]0.14 (0.30) [0.04]ns0.17 (0.27) [0.02]0.16 (0.33) [0.05]ns
T1 lesion SDGM volume0.05 (0.09) [0]0.03 (0.06) [0]ns0.03 (0.05) [0]0.03 (0.06) [0]ns
Caudate6.39 (0.98) [5.96]6.30 (0.87) [6.10]ns6.12 (0.91) [5.91]6.35 (0.94) [6.25]ns
Putamen9.21 (1.19) [9.48]9.33 (1.43) [9.10]ns9.19 (1.07) [9.48]9.40 (1.36) [9.16]ns
Globus pallidus3.35 (0.51) [3.29]3.46 (0.42) [3.37]ns3.41 (0.44) [3.48]3.49 (0.42) [3.41]ns
Thalamus14.45 (1.82) [14.38]15.06 (1.85) [15.23]ns14.63 (1.84) [15.04]15.37 (1.72) [15.35]ns
Hippocampus7.20 (0.82) [7.23]7.63 (1.26) [7.55]ns7.18 (0.96) [7.23]7.83 (1.17) [7.82]*
Amygdala2.74 (0.48) [2.78]2.80 (0.45) [2.79]ns2.75 (0.44) [2.71]2.88 (0.44) [2.83]ns
Accumbens0.88 (0.22) [0.85]0.88 (0.23) [0.90]ns0.83 (0.20) [.84]0.92 (0.23) [0.94]ns
  • Disability progression was measured using the Expanded Disability Status Scale.

  • The brain volume values are presented in litres, lesion volumes and SDGM volumes in millilitres, as mean, (SD), [median]. The differences between the disability progressing and non-progressing groups were calculated using Student t test and Mann–Whitney rank sum test, as appropriate.

  • *Trend at p<0.05.

  • ns, non-significant; SDGM, subcortical deep grey matter.