Table 1

Demographics and the proportion of cases in each group with the main clinical features of the new FTD clinical phenotypes

bvFTD (N=66)sv-PPA (N=31)nfv-PPA (N=16)lv-PPA (N=22)p Value
% male/% female65/3556/4365/3586/140.14
Age at onset (years)57 (10)61 (7)65 (8)62 (9)0.004
Age at diagnosis (years)61 (9)65 (7)70 (8)66 (8)0.002
Age at death (years)66 (10)73 (7)75 (7)71 (8)<0.0001
Duration from onset (years)9 (5)12 (4)10 (3)9 (3)0.012
Duration from diagnosis (years)5 (3)8 (3)6 (2)5 (4)0.001
Behavioural features
 Loss of empathy33281814
Stereotyped behaviours95722428*
 Alt. food pref.58504123
Executive deficits592560*
Language features
Word finding458471100*
Apraxia of speech569432*
Single word comp5841818*
 Object agnosia23405
Phonologic errors297173*
Word rep005364*
Sentence rep263568*
 Sentence Comprehension23728868
Surface dyslexia11817164*
Motor features
 Gait disturbance123129
Orobuccal apraxia83240*
Neuropsychiatric features
Other features
 Rigidity of thought41381218
  • *Features with high (>80%) and low (<20%) prevalences indicated and the patterns of features discriminating each clinical subtype statistically identified in bold (Wilks’ lambda=0.024, p<0.0001).

  • bvFTD, behavioural variant frontotemporal dementia; lv-PPA, logopenic variant-primary progressive aphasias; nfv-PPA, non-fluent/agrammatic variant-PPA; sv-PPA, semantic variant-PPA.