Demographics and the proportion of cases in each group with the main clinical features of the new FTD clinical phenotypes
| FTLD (N=102) | AD (N=33) | p Value | |
|---|---|---|---|
| % male/% female | 64/36 | 73/27 | 0.211 |
| Age at onset (years) | 58 (9) | 64 (10) | 0.002 |
| Age at diagnosis (years) | 62 (8) | 68 (9) | 0.002 |
| Age at death (years) | 68 (9) | 74 (8) | 0.003 |
| Duration from onset (years) | 10 (4) | 10 (6) | 0.884 |
| Duration from diagnosis (years) | 6 (3) | 6 (3) | 0.889 |
| Behavioural features | |||
| Disinhibition | 79 | 51.5 | – |
| Apathy | 58 | 36 | – |
| Loss of empathy | 29 | 18 | – |
| Stereotyped behaviours | 77 | 48 | – |
| Alt. food pref. | 55 | 24 | * |
| Executive deficits | 40 | 21 | – |
| Language features | |||
| Word finding | 61 | 85 | * |
| Apraxia of speech | 16 | 33 | – |
| Agrammatism | 7 | 15 | – |
| Naming | 56 | 73 | – |
| Single word comp | 27 | 24 | – |
| Object agnosia | 11 | 3 | * |
| Phonologic errors | 12 | 58 | * |
| Word rep | 8 | 42 | – |
| Sentence rep | 10 | 42 | * |
| Sentence Comprehension | 47 | 58 | – |
| Surface dyslexia | 36 | 64 | – |
| Motor features | |||
| Parkinsonism | 11 | 15 | – |
| Apraxia | 17 | 30 | – |
| Gait disturbance | 7 | 18 | * |
| Orobuccal apraxia | 8 | 3 | – |
| Neuropsychiatric features | |||
| Delusions | 8 | 18 | * |
| Hallucinations | 11 | 21 | * |
| Other features | |||
| Prosopagosia | 17 | 0 | – |
| Rigidity of thought | 34 | 24 | – |
| Irritability | 41 | 36 | – |
| Aggression | 27 | 18 | – |
*Features with high (>80%) and low (<20%) prevalences indicated and the patterns of features discriminating pathology type statistically identified in bold (Wilks’ lambda=0.596, p<0.0001).
AD, Alzheimer's disease; FTD, frontotemporal dementia; FTLD, frontotemporal lobar degeneration.