Table to show the summary of targets for DBS for the treatment of epilepsy
| Controlled trial | |||
|---|---|---|---|
| Target | Primary author | Year | Outcome |
| Anterior nucleus of the thalamus | Fisher | 2010 | SANTE trial: 40.4% median seizure reduction |
| Cerebellum | Van Buren | 1978 | 69% seizure reduction in 80% patients |
| Wright | 1984 | Ineffective | |
| Velasco | 2005 | >50% seizure reduction in 80% cases | |
| Centromedian nucleus of the thalamus | Fisher | 1992 | >50% seizure reduction in 80% cases |
| Velasco | 2000 | No significant difference | |
| Hippocampus | Tellez-Zenteno | 2006 | 15% seizure reduction |
| Velasco | 2007 | >50% seizure reduction in all 9 patients | |
| McLachlan | 2010 | 33% seizure reduction | |
| Caudate nucleus | None (case reports only) | ||
| Subthalamic nucleus | None (case reports only) | ||
| Corpus callosum/fornix | None (animal models only) | ||
| Posterior hypothalamic mammillary nuclei | None (case reports only) | ||
| Locus coeruleus | None (case reports only) | ||
Amended from Wu and Sharan.33
DBS, deep brain stimulation.