Clinical and OCT data of included eyes
| MSON eyes N=144 | MSNON eyes N=279 | HC eyes N=126 | p Value MSON versus MSNON† | p Value MSNON versus HC† | p Value MSON vs HC† | |
|---|---|---|---|---|---|---|
| Vision (N [%]) | ||||||
| 0-0.65 | 50 (37%) | 41 (16%) | - | |||
| ≥0.8 | 85 (63%) | 217 (84%) | ||||
| Relative values | ||||||
| Perimacular area | ||||||
| Retina | 100% | 100% | 100% | |||
| RNFL | 7.8% | 8.1% | 8.2% | <0.001* | 0.197 | <0.001* |
| GCC | 22.8% | 26.2% | 28.3% | <0.001* | <0.001* | <0.001* |
| INL | 13.9% | 13.0% | 12.4% | <0.001* | <0.001* | <0.001* |
| ORLs | 56.0% | 52.8% | 51.0% | <0.001* | <0.001* | <0.001* |
| Peripapillary area | ||||||
| Retina | 100% | 100% | 100% | |||
| RNFL | 26.4% | 28.4% | 29.3% | <0.001* | <0.001* | <0.001* |
| INL | 5.5% | 5.5% | 5.6% | 0.120 | 0.150 | 0.013 |
| OPL | 9.6% | 9.3% | 9.2% | <0.001* | 0.007 | <0.001* |
| ONL | 20.7% | 19.8% | 19.6% | <0.001* | 0.071 | <0.001* |
| Absolute values | ||||||
| Perimacular area | ||||||
| Retina | 306.6 (18.5) | 320.1 (17.7) | 332.6 (12.9) | <0.001* | <0.001* | <0.001* |
| RNFL | 24.0 (2.9) | 26.1 (2.7) | 27.3 (2.1) | <0.001* | <0.001* | <0.001* |
| GCC | 70.5 (17.3) | 84.2 (13.1) | 94.2 (6.0) | <0.001* | <0.001* | <0.001* |
| INL | 42.3 (3.0) | 41.5 (3.0) | 41.4 (2.9) | <0.001* | 0.518 | 0.014 |
| ORLs | 170.9 (8.9) | 168.3 (8.9) | 170.2 (8.9) | 0.006 | 0.158 | 0.927 |
| Peripapillary area | ||||||
| Retina | 289.3 (19.0) | 301.0 (17.0) | 312.2 (13.4) | <0.001* | <0.001* | <0.001* |
| RNFL | 76.4 (11.6) | 85.5 (10.1) | 91.7 (6.8) | <0.001* | <0.001* | <0.001* |
| INL | 15.9 (1.5) | 16.6 (1.2) | 17.5 (1.1) | <0.001* | <0.001* | <0.001* |
| OPL | 27.8 (1.6) | 28.0 (1.5) | 28.8 (1.5) | 0.001* | 0.002* | <0.001* |
| ONL | 59.8 (3.8) | 59.4 (3.7) | 61.3 (3.6) | 0.507 | 0.005 | 0.003* |
Eyes were stratified into those with (MSON) and without optic neuritis (MSNON) and healthy control (HC) eyes. The OCT data is presented as absolute (µm, mean±SD) and relative data (normalised as percentage of the individual retinal thickness). The significant highest values per retinal layer are shown in bold.
*GEE analyses with adjustment for age and intrasubject intereye correlation.
†p Value significant with Bonferroni correction: (N=16) 0.05/16=0.003.
GCC, ganglion cell complex; GEE, generalised estimation equations; HC, healthy control; INL, inner nuclear layer; MSON, MS eyes with optic neuritis; MSNON, MS eyes without optic neuritis; ns= not significant (p>0.003); OCT, optical coherence tomography; ONL, outer nuclear layer; OPL, outer plexiform layer; ORL, outer retinal layer; RNFL, retinal nerve fibre layer.