APOE allele frequencies according to age (age at onset for patients and age at inclusion for healthy controls)
| Age (years) | n | Allele frequencies (%) | |||
|---|---|---|---|---|---|
| ε2 | ε3 | ε4 | |||
| DLB | ≤65 | 30 | 3.3 | 60.0 | 36.7* |
| 66–79 | 100 | 4.0* | 62.0 | 34.0* | |
| ≥80 | 26 | 11.5 | 69.3 | 19.2 | |
| AD | ≤65 | 144 | 4.5 | 41.3 | 54.2* |
| 66–79 | 263 | 4.7* | 50.8 | 44.5*,† | |
| ≥80 | 112 | 9.8‡ | 65.6 | 24.6*,‡ | |
| Healthy controls | ≤65 | 59 | 10.2 | 72.0 | 17.8 |
| 66–79 | 426 | 9.9 | 76.3 | 13.8 | |
| ≥80 | 158 | 12.7 | 72.7 | 14.6 | |
*Significant difference between a patient group and the control group.
†Significant difference between the groups of patients with DLB or AD.
‡Significant difference in allele frequency according to age within the respective group (Pearson's χ2 test).
AD, Alzheimer's disease; DLB, dementia with Lewy bodies.