Table 2

Correlations between baseline NfL concentration and NfL area under the curve and motor, pinprick and light touch scores at different time points

DayBL47214284180365
Motor score
 n2722232323252424
 BL NfL−0.53ns−0.49ns−0.41−0.44−0.44−0.42
0.004 0.0190.0490.0280.0310.039
 24H NfL−0.69−0.56−0.64−0.69−0.68−0.72−0.69−0.73
*0.0070.001*****
 NfL AUC−0.74−0.73−0.68−0.72−0.80−0.82−0.79−0.82
********
Pinprick
 n2720232222252424
 BL NfLnsns−0.55−0.43nsnsnsns
 0.0070.046
 24H NfL−0.52−0.57−0.70−0.71−0.50ns−0.47ns
0.0010.008**0.0220.024
 NfL AUC−0.65−0.56−0.69−0.79−0.60−0.43−0.58−0.44
*0.011**0.0030.0330.0030.032
Light touch
 n2721222222252424
 BL NfLnsns−0.55−0.55nsnsnsns
 0.0080.008
 24H NfL−0.57−0.46−0.70−0.80−0.61−0.46−0.48ns
0.0020.037**0.0030.0250.022
 NfL AUC−0.62−0.51−0.62−0.85−0.74−0.58−0.63−0.49
0.0010.0170.002**0.0020.0010.016
  • Spearman r and p values are displayed; *p<0.001.

  • BL NfL, NfL measurement at baseline; 24H NfL, NfL measurement after 24 h; NfL AUC, NfL area under the curve over the 7 day sampling period; BL, baseline examination; n, number of patients at each time point (in days postbaseline).