Table 1

Demographic and neuropsychological variables

VariableNCAD1AD2PSP
Education17.8±1.616.1±4.3*15±1.15†15.8±2.3‡
Gender (M/F)26/1121/167/611/12
Age62.9±12.564.1±9.168.23±6.2368.0±6.7
ApoE4 status (non-carrier/carrier)15/1021/1616/3
Tau haplotype (H1/H2 vs H1/H1)6/1612/222/18
Disease durationNA4.5±3.6§6.3±2.6
CDR-total0¶,**0.7±0.70.4±0.5
CDR-sb0¶,**4.9±3.04.4±2.5
MMSE29.2±1.020.4±5.9*,§28.46±2.99††26.2±3.6‡
Rey15.5±0.712.1±4.5*13.1±1.9‡
Rey 10 m11.9±3.34.6±4.1*,§9.4±2.8‡
FDS7.4±0.84.8±1.5*5.6±1.3‡
BDS6.3±1.02.9±1.0*,§3.9±1.3‡
Phonemic fluency15.4±4.58.2±4.4*6.8±4.0‡
Category fluency25.0±4.19.8±5.5*10.9±4.2‡
BNT14.8±0.410.9±3.8*,§14.1±1.0
Trails correct14.0±08.8±5.3*12.8±2.4
UPDRS-III0.3±0.7¶,**9.0±12.2§32.1±8.2
CVLT 30 s8.4±1.13.2±2.0*,§6.7±1.6‡
CVLT 10 min8.3±1.42.0±2.4*,§6.3±2.0‡
  • *AD1<NC (p<0.05).

  • †NC<AD2 (p<0.05).

  • ‡PSP<NC (p<0.05).

  • §AD1<PSP (p<0.05).

  • ¶NC<AD1 (p<0.05).

  • **NC<PSP (p<0.05).

  • ††PSP<AD2 (p<0.05).

  • AD1, Alzheimer's disease in the original cohort; AD2, Alzheimer's disease in the second cohort; ApoE4 status, ApoE4 non-carrier vs carrier; BDS, Digit Span Backward; BNT, Boston naming task (out of 15); Categorical Fluency, number of animals in 1 min; CDR, Clinical Dementia Rating; CDR- sb, Clinical Dementia Rating sum of boxes; Disease duration, number of years from the onset of the disease to the date of CSF collection; CVLT 30 s and 10 min, number of correct items remembered on the California verbal learning task after a 30 s or 10 min delay; FDS, Digit Span Forward; MMSE, Mini-Mental State Examination; NC, normal control; Phonemic Fluency, number of correct words beginning with D in 1 min; PSP, progressive supranuclear palsy; Rey and Rey10, Benson Figure copy test immediate recall and 10 min delayed recall; Trails Correct, Modified Trail-making test number of correct items; UPDRS-III, Unified Parkinson's Disease Rating Scale–part III motor scale.