Table 2

Unadjusted and adjusted univariate survival analysis results

Unadjusted analysisAdjusted analysis*
VariableHR (95% CI)p ValueHR (95% CI)p Value
Sex
 Female1.000
 Male1.266 (1.060 to 1.511)0.009
Age at onset (year)1.039 (1.031 to 1.046)<0.001
BMI (kg/m2)0.958 (0.925 to 0.992)0.0160.959 (0.925 to 0.994)0.021
Diagnostic delay from symptom onset (months)0.953 (0.946 to 0.959)<0.0010.950 (0.943 to 0.957)<0.001
Phenotype
 Limb-onset ALS1.0001.000
 Bulbar-onset ALS1.531 (1.220 to 1.921)<0.0011.323 (1.050 to 1.667)0.017
 FAS0.787 (0.576 to 1.075)0.1320.578 (0.420 to 0.795)0.001
 PMA0.794 (0.466 to 1.353)0.3960.795 (0.466 to 1.358)0.402
 PLS0.000 (0.000 to 1.709E81)0.9130.000 (0.000 to 1.139E84)0.914
Airlie House category
 Clinically definite1.0001.000
 Clinically probable0.943 (0.745 to 1.195)0.6290.861 (0.679 to 1.091)0.216
 Laboratory-supported probable0.624 (0.440 to 0.885)0.0080.567 (0.400 to 0.805)0.001
 Clinically possible0.821 (0.641 to 1.053)0.1200.687 (0.535 to 0.884)0.003
 Suspected0.740 (0.467 to 1.171)0.1990.714 (0.449 to 1.136)0.156
Place of residence
 Urban1.0001.000
 Rural1.202 (1.010 to 1.431)0.0391.436 (1.202 to 1.716)<0.001
  • Other factors that did not reach statistical significance in the analysis are not shown in the table.

  • *The analysis is adjusted for age at onset and sex.

  • ALS, amyotrophic lateral sclerosis; BMI, body mass index; FAS, flail arm syndrome; PLS, primary lateral sclerosis; PMA, progressive muscular atrophy.