Frequency of serum antibodies against EBV-specific antigens
| Positivity rate | p Value | |||||
|---|---|---|---|---|---|---|
| Titre | NMO (n=50) | MS (n=51) | HC (n=52) | NMO vs MS | NMO vs HC | MS vs HC |
| VCA IgM | 4/50 (8.0%) | 4/51 (7.8%) | 2/52 (3.9%) | NS | NS | NS |
| VCA IgG | 38/50 (76%) | 48/51 (94%) | 42/52 (81%) | 0.01 | NS | NS |
| EA IgM | 2/50 (4.0%) | 1/51 (1.9%) | 0/52 (0.0%) | NS | NS | NS |
| EA IgG | 26/50 (52%) | 13/51 (26%) | 13/52 (25%) | 0.005 | 0.005 | NS |
| EBNA-1 IgG | 49/50 (98%) | 50/51 (98%) | 47/52 (90%) | NS | NS | NS |
EA, early antigen; EBNA, EBV nuclear antigen; EBV, Epstein-Barr virus; HC, healthy control; MS, multiple sclerosis; NS, not significant; NMO, neuromyelitis optica; VCA, viral capsid antigen.