HRs for clinically definite multiple sclerosis according to the multivariate analysis
| Variable | n | Events | HR (95% CI) | p Value | |
|---|---|---|---|---|---|
| Age | <30 | 52 | 21 | 1 (ref) | –* |
| 30–40 | 40 | 16 | 0.8 (0.3 to 1.9) | 0.63 | |
| >40 | 35 | 15 | 0.4 (0.1 to 1.2) | 0.09 | |
| Sex | Male | 29 | 8 | 1 (ref) | – |
| Female | 98 | 44 | 1.3 (0.6 to 3.1) | 0.52 | |
| DIS criteria McDonald 2010 | Not fulfilled | 45 | 12 | 1 (ref) | – |
| Fulfilled | 70 | 34 | 1.7 (0.7 to 4.4) | 0.27 | |
| Gadolinium enhancement | No | 45 | 16 | 1 (ref) | – |
| Yes | 31 | 19 | 1.8 (0.7 to 5.0) | 0.22 | |
| Vitamin D | <50 | 31 | 16 | 0.9 (0.3 to 2.1) | 0.75 |
| >50 | 73 | 26 | 1 (ref) | – | |
| Fatigue | No | 68 | 20 | 1 (ref) | – |
| Yes | 59 | 32 | 4.5 (1.9 to 10.6) | 0.001 | |
| Anxiety | No | 79 | 31 | 1 (ref) | – |
| Yes | 45 | 20 | 0.9 (0.4 to 2.2) | 0.89 | |
| Depression | No | 97 | 39 | 1 (ref) | – |
| Yes | 27 | 12 | 1.7 (0.6 to 5.0) | 0.34 | |
| Symptom localisation | Optic nerve | 42 | 14 | 1 (ref) | – |
| Spinal cord | 35 | 13 | 1.0 (0.3 to 3.1) | 0.98 | |
| Brain stem | 12 | 6 | 0.4 (0.1 to 1.1) | 0.25 | |
| Multiregional | 22 | 11 | 3.2 (1.1 to 9.4) | 0.03 | |
| Other | 15 | 8 | 1.3 (0.4 to 5.0) | 0.67 |
Events=a diagnosis of clinically definite MS.
*p for trend 0.22.
DIS, dissemination in space.