Table 3

Multivariate Cox regression analysis

VariableHR (95%CI)p Value
Sex
 Female1.000
 Male1.704 (1.186 to 2.448)0.004
Age at onset (year)1.045 (1.031 to 1.060)<0.001
BMI (kg/m2)0.943 (0.897 to 0.990)0.019
Diagnostic delay from symptom onset (month)0.913 (0.897 to 0.929)<0.001
Phenotype
 Limb-onset ALS1.000
 Bulbar-onset ALS1.590 (1.097 to 2.304)0.014
 FAS1.721 (0.928 to 3.191)0.085
 PMA1.255 (0.271 to 5.817)0.772
 PLS0.000 (0.000 to 3.75E168)0.967
Category
 Clinically definite1.000
 Clinically probable0.672 (0.466 to 0.970)0.034
 Laboratory-supported probable0.368 (0.214 to 0.633)<0.001
 Clinically possible0.469 (0.294 to 0.748)0.001
 Suspected0.769 (0.198 to 2.197)0.498
History of contact with pesticides2.016 (1.372 to 2.963)<0.001
Traditional Chinese medicine1.481 (0.955 to 2.297)0.080
  • Other factors that did not reach statistical significance in the analysis are not shown in the table.

  • ALS, amyotrophic lateral sclerosis; BMI, body mass index; FAS, flail arm syndrome; PLS, primary lateral sclerosis; PMA, progressive muscular atrophy.