Multivariate Cox regression analysis
| Variable | HR (95%CI) | p Value |
|---|---|---|
| Sex | ||
| Female | 1.000 | |
| Male | 1.704 (1.186 to 2.448) | 0.004 |
| Age at onset (year) | 1.045 (1.031 to 1.060) | <0.001 |
| BMI (kg/m2) | 0.943 (0.897 to 0.990) | 0.019 |
| Diagnostic delay from symptom onset (month) | 0.913 (0.897 to 0.929) | <0.001 |
| Phenotype | ||
| Limb-onset ALS | 1.000 | |
| Bulbar-onset ALS | 1.590 (1.097 to 2.304) | 0.014 |
| FAS | 1.721 (0.928 to 3.191) | 0.085 |
| PMA | 1.255 (0.271 to 5.817) | 0.772 |
| PLS | 0.000 (0.000 to 3.75E168) | 0.967 |
| Category | ||
| Clinically definite | 1.000 | |
| Clinically probable | 0.672 (0.466 to 0.970) | 0.034 |
| Laboratory-supported probable | 0.368 (0.214 to 0.633) | <0.001 |
| Clinically possible | 0.469 (0.294 to 0.748) | 0.001 |
| Suspected | 0.769 (0.198 to 2.197) | 0.498 |
| History of contact with pesticides | 2.016 (1.372 to 2.963) | <0.001 |
| Traditional Chinese medicine | 1.481 (0.955 to 2.297) | 0.080 |
Other factors that did not reach statistical significance in the analysis are not shown in the table.
ALS, amyotrophic lateral sclerosis; BMI, body mass index; FAS, flail arm syndrome; PLS, primary lateral sclerosis; PMA, progressive muscular atrophy.