Table 1

Subject characteristics

PatientsControlsp Value
N22262
Age (years)54.1 (±10.0)50.5 (±7.3)0.002*
Sex (% male)32.035.50.603†
MS type (N (%))
RR137 (61.7)n/a
SP57 (25.7)
PP28 (12.6)
Disease duration (years)20.3 (±7.0)n/a
EDSS (median [range])4.0 [1–8]n/a
History of MSON (N (%))102 (45.9)n/a
 Bilateral MSON38 (17.1)
 Bilateral MSNON103 (46.4)
  • *independent sample t test.

  • †χ2 test.

  • EDSS, expanded disability status scale; MS, multiple sclerosis; MSNON, MS without optic neuritis; MSON, MS optic neuritis; PP, primary progressive; RR, relapsing remitting; SP, secondary progressive.