Table 3

MRI abnormality (volume loss and/or lesions) in ROIs significantly associated with poorer clinical function

Domain	ROI	Total GM volume				GM lesion volume
Domain	ROI	B	SE	p Value	Adj R²	B	SE	p Value	Adj R²
EDSS	Cerebellum	−0.053	0.022	0.018	0.203	2.562	0.960	0.009	0.216
EDSS	Postcentral gyrus	−0.294	0.093	0.002	0.242	5.441	2.326	0.022	0.199
Executive function	Cerebellum	0.042	0.015	0.006	0.067	−1.567	0.665	0.021	0.038
Memory function	Cerebellum	0.026	0.011	0.020	0.066	−1.205	0.483	0.015	0.072
Memory function	Postcentral gyrus					−2.695	1.164	0.023	0.062
z25TWT	Cerebellum	0.014	0.006	0.020	0.156	−0.543	0.244	0.029	0.148
z25TWT	Postcentral gyrus	0.062	0.024	0.014	0.164	−1.574	0.574	0.008	0.176
zPASAT	Cerebellum	0.047	0.012	<0.001	0.150
	Insula	0.336	0.099	0.001	0.122
	Medial temporal lobe	0.286	0.094	0.003	0.098
	Postcentral gyrus					−2.842	1.399	0.032	0.076
	Prefrontal lobe	0.026	0.011	0.025	0.052
z9HPT	Cerebellum	0.023	0.009	0.016	0.100

If both volume loss and increased lesion burden is associated, the strongest contributor is presented in bold.
EDSS, Expanded Disability Status Scale; GM, grey matter; z9HPT, 9-hole Peg Test; 25TWT, 25-foot Timed Walk Test; zPASAT, Paced Auditory Serial Addition Test, ROI, region of interest.