Regions | Side | Coordinates (x, y, z) | Mean nodal efficiency (SD) | p Value | CN vs LLD | CN vs aMCI | CN vs aMCI-LLD | LLD vs aMCI | LLD vs aMCI-LLD | aMCI vs aMCI-LLD | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CN | LLD | aMCI | aMCI-LLD | ||||||||||||||
dACC | R | (5, −18, 34) | 0.584 | (0.032) | 0.564 | (0.034) | 0.562 | (0.030) | 0.551 | (0.035) | 0.0040 | * | * | * | |||
VMPFC | R | (3, −44, −9) | 0.561 | (0.030) | 0.572 | (0.040) | 0.576 | (0.046) | 0.527 | (0.040) | 0.0048 | * | * | * | |||
MTG | R | (52, 63, 5) | 0.569 | (0.037) | 0.570 | (0.034) | 0.584 | (0.041) | 0.527 | (0.051) | 0.0040 | * | * | * | |||
TP | L | (−46, −16, −30) | 0.575 | (0.034) | 0.564 | (0.040) | 0.587 | (0.045) | 0.532 | (0.034) | 0.0029 | * | * | * | |||
Insula | L | (−34, −16, −8) | 0.585 | (0.034) | 0.584 | (0.036) | 0.583 | (0.041) | 0.529 | (0.047) | 0.0003 | * | * | * | |||
MCC | R | (14, 18, 40) | 0.555 | (0.049) | 0.526 | (0.060) | 0.554 | (0.037) | 0.492 | (0.069) | 0.0036 | * | * | ||||
PreCG | R | (7, 33, 72) | 0.578 | (0.032) | 0.557 | (0.046) | 0.573 | (0.039) | 0.529 | (0.043) | 0.0064 | * | * | ||||
PreCG | L | (−13, 33, 75) | 0.584 | (0.030) | 0.574 | (0.040) | 0.578 | (0.048) | 0.519 | (0.056) | 0.0003 | * | * | * | |||
ParaCG | L | (−10, 17, 74) | 0.575 | (0.033) | 0.567 | (0.044) | 0.591 | (0.042) | 0.537 | (0.032) | 0.0046 | * | * | * | |||
SFG | R | (16, 5, 71) | 0.562 | (0.028) | 0.564 | (0.040) | 0.594 | (0.033) | 0.540 | (0.047) | 0.0058 | * | * | ||||
SPC/Precu | L | (−25, 58, 60) | 0.573 | (0.041) | 0.560 | (0.047) | 0.569 | (0.043) | 0.512 | (0.075) | 0.0025 | * | * |
Bold indicates comparisons survived after FDR correction (q<0.05 and p<0.0005).
*Significant between-group differences based in the non-parametric post hoc tests.
aMCI, amnestic mild cognitive impairment; aMCI-LLD, late-life depression comorbid with amnestic mild cognitive impairment; CN, cognitively normal; dACC, dorsal anterior cingulate cortex; LLD, late-life depression; MCC, middle cingulate cortex; MTG, middle temporal gyrus; ParaCG, paracentral gyrus; PreCG, precentral gyrus; Precu, precuneus; SFG, superior frontal gyrus; SPC, superior parietal cortex; TP, temporal pole; VMPFC, ventromedial prefrontal cortex.