Demographic features of 40 patients with CCPD
| Basic demographics | N=40 |
| Sex ratio (male/female) | 11:29 |
| Age at onset (years, mean±SD) | 31.7±14.1 |
| Age at examination (years, mean±SD) | 36.5±14.6 |
| Follow-up period (months, mean±SD)* | 93.0±91.8 |
| Disease duration (months, mean±SD)* | 137.9±124.8 |
| Mode of onset | n/N (%) |
| Acute | 6/31 (19.4) |
| Subacute | 14/31 (45.2) |
| Chronic | 11/31 (35.5) |
| Clinical course | n/N (%) |
| Monophasic | 10/38 (26.3) |
| Relapse–remitting | 20/38 (52.6) |
| Chronic progressive | 8/38 (21.1) |
| Initial symptoms | n/N (%) |
| Related to CNS involvement | 15/38 (39.5) |
| Related to PNS involvement | 15/38 (39.5) |
| Simultaneous or sequential | 8/38 (21.0) |
| Fulfilment of MS or CIDP criteria | n/N (%) |
| McDonald criteria for MS | 27/40 (67.5) |
| EFNS/PNS definite criteria for CIDP | 35/40 (87.5) |
| Symptoms and signs during the entire course | n/N (%) |
| Seizure† | 3/40 (7.5) |
| Mental disturbance† | 5/40 (12.5) |
| Visual disturbance† | 19/40 (47.5) |
| Right | 1/19 (5.3) |
| Left | 8/19 (42.1) |
| Bilateral | 10/19 (52.6) |
| Cranial nerve involvement (other than the optic nerves) | 17/39 (43.6) |
| Motor weakness‡ | 37/40 (92.5) |
| Hemiplegia† | 10/36 (27.8) |
| Paraplegia† | 6/36 (16.7) |
| Weakness of 4 extremities§ | 24/36 (66.7) |
| Muscle atrophy§ | 11/40 (27.5) |
| Respiratory disturbance | 3/40 (7.5) |
| Gait disturbance | 31/39 (79.5) |
| Cerebellar ataxia† | 10/38 (26.3) |
| Sensory disturbance | 37/39 (94.9) |
| Half-body involvement† | 5/37 (13.5) |
| Sensory level† | 14/37 (37.8) |
| Glove and stocking type§ | 22/37 (59.4) |
| Other types | 3/37 (8.1) |
| Deep tendon reflexes | |
| Hyporeflexia§ | 26/40 (65.0) |
| Normal | 1/40 (2.5) |
| Hyper-reflexia† | 9/40 (22.5) |
| Both hyporeflexia and hyper-reflexia | 4/40 (10.0) |
| Pathological reflexes† | 18/40 (45.0) |
| Sphincter disturbance† | 18/38 (47.4) |
*Two patients’ data were missing.
†Symptoms derived from CNS involvement.
‡Detail of motor weakness in one patient was unknown.
§Symptoms derived from PNS involvement.
CCPD, combined central and peripheral demyelination; CIDP, chronic inflammatory demyelinating polyradiculoneuropathy; CNS, central nervous system; n, number of involved cases; N, number of cases collated; MS, multiple sclerosis; PNS, peripheral nervous system.