Table 2

Analysis of the effect of steroid use, cohort and genotype on age at wheelchair dependence

HR*p Value
SPP1
Steroid use0.38<0.001
SPP1 SNP
 TT1.040.73
 GT/GG1‡
Cohort
 London1.120.60
 Ferrara1.720.01
 Montpellier1.820.002
 Leiden1.80.006
 Newcastle1‡
LTBP4
Additive model
 Steroid use0.31<0.001
LTBP4 haplotype
 IAAM0.80.046
 VTTT1‡
 other1.160.29
Cohort
 London1.160.47
 Ferrara1.620.03
 Montpellier1.070.79
 Leiden1.830.005
 Newcastle1‡
Recessive model
 Steroid use0.31<0.001
LTBP4 diplotypes
 IAAM/IAAM1‡
 other diplotypes1.30.01
Cohort
 London1.180.44
 Ferrara1.690.02
 Montpellier1.080.75
 Leiden1.880.003
 Newcastle1‡
  • *HR above 1 point to an earlier loss of ambulation compared to the reference, while HRs below 1 point to a later loss of ambulation compared to the reference.

  • The reported values were obtained using a dominant model for the SPP1 SNP and additive and recessive models for the LTBP4 haplotype.

  • ‡These conditions were used as reference, therefore their HRs are set at 1.

  • SNP, single nucleotide polymorphism.