Diagnostic tests, treatment and outcome description
| Number | MRI; time to 1st MRI (days) | EEG | Autoimmune disease | Tumour; latency to diagnosis (days) | Treatment | Outcome; months | |||
|---|---|---|---|---|---|---|---|---|---|
| FLAIR/T2 increased signal | CLN | EP | Slowing | Time to 1st EEG (days) | |||||
| 1 | Normal; 10 | – | Left temporal | – | 7 | – | – | Steroids+rituximab+IVIg+PLEX | No improvement; 4 |
| 2 | Unilateral mediotemporal, extratemporal; 4 | – | – | – | 3 | – | – | Steroids+rituximab+cyclophosphamide | Death/SUDEP (autopsy done); 12 |
| 3 | Unilateral mediotemporal; 2 | – | – | Frontal and generalised | 2 | – | SCLC; 15 | Steroids+immunoadsorption | Sopor; 1 |
| 4 | Bilateral mediotemporal; 10 | + | – | Generalised | 8 | – | SCLC; 35 | Chemotherapy | Death (no autopsy); 3 |
| 5 | Bilateral mediotemporal; 1 | – | – | Generalised | 1 | – | SCLC; 36 | Steroids+IVIg, PLEX+Chemotherapy | Sopor, psychosyndrom with hallucinations; 2 |
| 6 | Unilateral mediotemporal; 6 | + | Right-sided | – | 4 | – | Lung cancer; 18 | Steroids+azathioprin+chemotherapy | Improved memory; 6 |
| 7 | Unilateral mediotemporal; 3 | – | PLEDs (left) | Left-sided and generalised | 259 | – | SCLC; 0 | Chemotherapy+radiotherapy | Death due to aspiration pneumonia (autopsy done);9 |
| 8 | Bilateral mediotemporal, temporal lobe, extratemporal; 2 | – | – | Right and left frontotemporal | 0 | – | – | Steroids+immunoadsorption | No improvement; 3 |
| 9 | Unilateral mediotemporal; 6 | – | – | – | 0 | – | – | IVIg | No information; 2 |
| 10 | Unilateral mediotemporal; 3 | + | Left temporal | Left frontotemporal | 2 | – | – | IVIg | Complete remission; 2 |
| 11 | Bilateral mediotemporal; 22 | + | – | – | 4 | – | – | Steroids+azathioprine | Improved memory; 5 |
| 12 | Bilateral mediotemporal; 5 | – | – | – | 5 | – | – | Steroids+rituximab+IVIg+PLEX | Fluctuation, no recovery;6 |
| 13 | Bilateral mediotemporal; 0 | + | – | – | – | Hashimoto thyroiditis | Ovarial adenocarcinoma; 11 | Steroids+mycophenolate mofetil+IVIg+PLEX+ chemotherapy | Improved memory; 14 |
CLN, cortical laminar necrosis (hippocampus); EP, epileptiform potentials; FLAIR, fluid-attenuated inversion recovery; IVIg, intravenous immunoglobulins; PLEDs, periodic lateralised epileptiform discharges; PLEX, plasma exchange; SCLC, small cell lung cancer; SUDEP, sudden unexpected death in epilepsy.