Biomarker concentrations and routine CSF parameters for MND-mimics (patients who were seen under the differential diagnosis of an MND)
| Diagnosis MND mimics | n | NfL (pg/mL) | pNfH (pg/mL) | Tau (pg/mL) | pTau (pg/mL) | Qalb | Total protein (µg/mL) |
|---|---|---|---|---|---|---|---|
| Polyneuropathy | 17 | 943 216–3535 | 368 62–1331 | 211 98–396 | 38 15–78 | 6.5 3.0–22.2 | 527 254–1360 |
| Myopathy | 10 | 835 277–9165 | 361 62–2653 | 157 82–408 | 48 15–61 | 6.1 3.4–9.4 | 472 310–755 |
| Myositis | 9 | 923 405–3266 | 288 174–2096 | 351 149–396 | 56 40–100 | 5.9 5–9.7 | 504 446–802 |
| Hereditary spastic paraplegia | 8 | 495 168–937 | 189 62–318 | 174 92–278 | 44 15–53 | 5.7 2.7–1.2 | 439 205–906 |
| Benign fasciculations | 5 | 681 469–7622 | 242 90–4160 | 266 238–345 | 50 40–68 | 5.9 3.6–8.8 | 458 303–680 |
| Chronic inflammatory demyelinating polyneuropathy | 5 | 3548 330–10 000 | 1264 205–10 000 | 262 135–563 | 48 24–70 | 10.6 4.8–50 | 925 381–2750 |
| Myelitis | 5 | 921 570–1988 | 362 166–1038 | 125 114–568 | 29 17–82 | 7.1 5.4–15.1 | 554 444–1020 |
| Exclusion | 4 | 529 338–1502 | 137 93–225 | 280 173–318 | 46 40–68 | 4.9 4.5–10.2 | 475 385–714 |
| Crampus syndrome | 2 | 763 674–851 | 236 222–250 | 164 116–211 | 39 28–50 | 5.7 4.8–6.6 | 416 384–448 |
| Mononeuritis multiplex | 2 | 954 917–990 | 165 129–201 | 180 149–211 | 32 27–37 | 10.3 8.7–11.8 | 779 600–958 |
| Peroneus lesion | 2 | 975 415–1534 | 243 101–384 | 312 106–518 | 41 27–55 | 5.5 4.1–6.9 | 406 297–515 |
| Radiculopathy | 2 | 2989 1598–4380 | 1141 358–1923 | 289 168–410 | 58 55–61 | 6.4 6.3–6.4 | 523 521–524 |
| Arm plexus lesion | 1 | 560 | 148 | 250 | 32 | 9.1 | 643 |
| Benign paroxysmal positional vertigo | 1 | 1241 | 446 | 135 | 30 | 9.7 | 711 |
| Chronic pain syndrome | 1 | 1932 | 806 | 269 | 29 | 6.2 | 579 |
| Encephalitis | 1 | 3498 | 1293 | 279 | 66 | 4.6 | 371 |
| Hyper-CKaemia | 1 | 178 | 73 | 97 | 34 | – | – |
| Multiple sclerosis | 1 | 256 | 112 | 252 | 29 | 4.3 | 388 |
| Neuralgic shoulder amyotrophy | 1 | 564 | 276 | 238 | 44 | 8.2 | 612 |
| Osteodegeneration of spine | 1 | 1119 | 526 | 276 | 37 | 5.4 | 515 |
| Paraneoplastic syndrome | 1 | 572 | 232 | 193 | 44 | 9.5 | 761 |
| Small vessel disease | 1 | 1996 | 548 | 224 | 52 | 3.8 | 350 |
| Somatisation disorder | 1 | 703 | 152 | 111 | 24 | 5.6 | 400 |
| Anterior spinal artery syndrome | 1 | 891 | 274 | 131 | 45 | 8.1 | 617 |
| Spinocerebellar ataxia | 1 | 1161 | 799 | 600 | 49 | 3.9 | 335 |
| Vasculitis | 1 | 654 | 475 | 279 | 47 | 6.5 | 614 |
Given are the median values and ranges.
CSF, cerebrospinal fluid; MND, motoneurons disease; NfL, neurofilament light chain; pNfH, phosphorylated heavy chain; pTau, phospho-tau protein; Qalb, CSF/serum albumin ratio; Tau, tau protein.