Table 4

Frequency of CV risk factors in patients with CIS, RRMS and PMS

CIS (n=61)RR (n=326)PMS (n=163)p Value
Individual CV risk factors, n (%)*
Overweight/obesity35 (57.4)194 (59.5)79 (48.5)0.052
 BMI <18.51 (1.6)7 (2.1)7 (4.3)0.246
 BMI ≥18.5–24.921 (34.4)109 (33.4)69 (42.3)
 BMI ≥25–29.921 (34.4)110 (33.7)50 (30.7)
 BMI ≥3014 (23)84 (25.8)29 (17.8)
Smoking31 (50.8)156 (47.9)92 (56.4)0.232
Hypertension20 (32.8)95 (29.1)53 (32.5)0.748
Heart disease14 (23)75 (23)28 (17.2)0.265
Type 1 diabetes0 (0)2 (0.6)0 (0)0.503
Two or more overall CV risk factors, n (%)35 (57.4)163 (50)81 (49.7)0.571
Specific combinations, n (%)
 Heart disease and hypertension4 (6.6)24 (7.4)11 (6.7)0.704
 Heart disease and smoking7 (11.5) 41 (12.6)17 (10.4)0.704
 Heart disease and BMI ≥257 (11.5) 53 (16.3)15 (9.2)0.069
 Hypertension and smoking10 (16.4) 47 (14.4)31 (19.0)0.440
 Hypertension and BMI ≥2518 (29.5) 67 (20.6)30 (18.4)0.260
 Smoking and BMI ≥2518 (29.5) 96 (29.4)42 (25.8)0.641
Three or more overall CV risk factors, n (%)10 (16.4)67 (20.6)25 (15.3)0.248
Specific combinations, n (%)
 Heart disease and hypertension and smoking4 (6.6)13 (4.0)6 (3.7)0.637
 Heart disease and hypertension and BMI ≥253 (4.9)19 (5.8)8 (4.9)0.883
 Heart disease and smoking and BMI ≥254 (6.6)30 (9.2)10 (6.1)0.437
 Hypertension and smoking and BMI ≥258 (13.1)35 (10.7)16 (9.8) 0.829
  • Differences between groups were calculated by using Fisher's exact test or χ2 test.

  • *Among patients with CIS, the following CV risk factor data were not collected: 4 (6.6%) for BMI, 1 (1.6%) for heart disease category, 2 (3.3%) for hypertension category, 2 (3.3%) for type 1 diabetes and none for smoking. Among patients with RRMS, the following CV risk factor data were not collected: 16 (4.9%) for BMI, 13 (4%) for heart disease category, 21 (6.4%) for hypertension category, 6 (1.8%) for type 1 diabetes and 7 (2.1%) for smoking. Among patients with PMS, the following CV risk factor data were not collected: 8 (4.9%) for BMI, 13 (7.9%) for heart disease category, 13 (7.9%) for hypertension category, 3 (1.8%) for type 1 diabetes and 2 (1.2%) for smoking.

  • BMI, body mass index; CIS, clinically isolated syndrome; CV, cardiovascular; PMS, progressive multiple sclerosis; RR, relapsing–remitting; RRMS, RR multiple sclerosis.