Frequency of CV risk factors in patients with CIS, RRMS and PMS
| CIS (n=61) | RR (n=326) | PMS (n=163) | p Value | |
|---|---|---|---|---|
| Individual CV risk factors, n (%)* | ||||
| Overweight/obesity | 35 (57.4) | 194 (59.5) | 79 (48.5) | 0.052 |
| BMI <18.5 | 1 (1.6) | 7 (2.1) | 7 (4.3) | 0.246 |
| BMI ≥18.5–24.9 | 21 (34.4) | 109 (33.4) | 69 (42.3) | |
| BMI ≥25–29.9 | 21 (34.4) | 110 (33.7) | 50 (30.7) | |
| BMI ≥30 | 14 (23) | 84 (25.8) | 29 (17.8) | |
| Smoking | 31 (50.8) | 156 (47.9) | 92 (56.4) | 0.232 |
| Hypertension | 20 (32.8) | 95 (29.1) | 53 (32.5) | 0.748 |
| Heart disease | 14 (23) | 75 (23) | 28 (17.2) | 0.265 |
| Type 1 diabetes | 0 (0) | 2 (0.6) | 0 (0) | 0.503 |
| Two or more overall CV risk factors, n (%) | 35 (57.4) | 163 (50) | 81 (49.7) | 0.571 |
| Specific combinations, n (%) | ||||
| Heart disease and hypertension | 4 (6.6) | 24 (7.4) | 11 (6.7) | 0.704 |
| Heart disease and smoking | 7 (11.5) | 41 (12.6) | 17 (10.4) | 0.704 |
| Heart disease and BMI ≥25 | 7 (11.5) | 53 (16.3) | 15 (9.2) | 0.069 |
| Hypertension and smoking | 10 (16.4) | 47 (14.4) | 31 (19.0) | 0.440 |
| Hypertension and BMI ≥25 | 18 (29.5) | 67 (20.6) | 30 (18.4) | 0.260 |
| Smoking and BMI ≥25 | 18 (29.5) | 96 (29.4) | 42 (25.8) | 0.641 |
| Three or more overall CV risk factors, n (%) | 10 (16.4) | 67 (20.6) | 25 (15.3) | 0.248 |
| Specific combinations, n (%) | ||||
| Heart disease and hypertension and smoking | 4 (6.6) | 13 (4.0) | 6 (3.7) | 0.637 |
| Heart disease and hypertension and BMI ≥25 | 3 (4.9) | 19 (5.8) | 8 (4.9) | 0.883 |
| Heart disease and smoking and BMI ≥25 | 4 (6.6) | 30 (9.2) | 10 (6.1) | 0.437 |
| Hypertension and smoking and BMI ≥25 | 8 (13.1) | 35 (10.7) | 16 (9.8) | 0.829 |
Differences between groups were calculated by using Fisher's exact test or χ2 test.
*Among patients with CIS, the following CV risk factor data were not collected: 4 (6.6%) for BMI, 1 (1.6%) for heart disease category, 2 (3.3%) for hypertension category, 2 (3.3%) for type 1 diabetes and none for smoking. Among patients with RRMS, the following CV risk factor data were not collected: 16 (4.9%) for BMI, 13 (4%) for heart disease category, 21 (6.4%) for hypertension category, 6 (1.8%) for type 1 diabetes and 7 (2.1%) for smoking. Among patients with PMS, the following CV risk factor data were not collected: 8 (4.9%) for BMI, 13 (7.9%) for heart disease category, 13 (7.9%) for hypertension category, 3 (1.8%) for type 1 diabetes and 2 (1.2%) for smoking.
BMI, body mass index; CIS, clinically isolated syndrome; CV, cardiovascular; PMS, progressive multiple sclerosis; RR, relapsing–remitting; RRMS, RR multiple sclerosis.