Variable | FC (n=100) (n (%) or median (IQR)) | NC (n=98) (n (%) or median (IQR)) | HC (n=92) (n (%) or median (IQR)) |
---|---|---|---|
Age (years) | 30.6 (25.1–37.9) | 31.6 (27.4–37.8) | 35.0 (29.0–45.0) |
Sex (F) | 67 (67) | 61 (62.2) | 58 (63.0) |
OCB (positive) | 87 (87) | 60 (61.2) | – |
T2 lesion count | |||
(0–1) | 5 (5) | 21 (21.4) | – |
(2–9) | 38 (38) | 52 (53.1) | – |
(>9) | 57 (57) | 25 (25.5) | – |
Gd+ lesions (positive) | 46 (58.2) | 25 (37.3) | – |
EDSS | 2.0 (1.5–3.0) | 1.5 (1.0–2.0) | – |
EDSS | |||
0–1.0 | 19 (21.3) | 31 (38.3) | – |
1.5–2.0 | 34 (38.2) | 39 (48.1) | – |
>2.0 | 36 (40.4) | 11 (13.6) | – |
NfL (pg/mL) | 24.1 (13.5–51.8) | 19.3 (13.6–35.2) | 7.9 (5.6–17.2) |
Two NC patients had insufficient sample volume and were therefore excluded.
CDMS, clinically definite multiple sclerosis; CIS, clinically isolated syndrome; EDSS, expanded disability status scale; FC, fast converters to CDMS; Gd+, gadolinium-enhancing MRI lesions; HC, healthy controls; NC, non-converters to CDMS; NfL, neurofilament light chain in serum; OCB, oligoclonal bands in cerebrospinal fluid; T2, T2 hyperintense MRI lesions.