Table 1

Characteristics of included studies

StudyStudy designPatients, numberMean age (years)Initial Stroke severity (Mean NIHSS)Intravenous rt-PA, %Recanalisation, %Favourable outcome, %sICH, %Mortality, %, delayTime to recanalization, h
Andersson et al11  Retrospective, single centre28–––6457021, 3 months–
Baek et al12Prospective, single centre256811249648012, 3 months5.1
Costalat et al13Prospective, single centre16––628144625, 3 months9.3
Dorn et al14Retrospective, single centre24–16.1–71––46, discharge–
Espinosa et al15Restrospective, single centre186720.4–9450022, discharge7.3
Fesl et al16Retrospective, single centre1173–118236036 discharge–
Lefevre et al17Retrospective, single centre256920.3–9256440 3 months–
Lyon HospitalRetrospective, single centre2260–3673271445, 3 months8
Miteff et al18Retrospective, single centre105426.30100201030, discharge13.6
Mohlenbruch et al19Prospective, single centre247024877533429, 3 months5.5
Mordasini et al20Prospective, single centre146421367929036, discharge7.6
Mourand et al21Propsective, single centre3161146174351632, 3 months8.5
Nagel et al22Prospective, single centre3670–648331336, 3 months–
Park et al23Retrospective, single centre166812.225445606, 3 months7.4
Raoult et al24Retrospective, single centre125418.81710058825, discharge7.8

  • Successful recanalisation defined as a Thrombolysis In Cerebral Infarction score of 2b or 3; Favourable outcome defined as an mRS score of 2 or less; sICH was defined as any parenchymal haematoma, subarachnoid haemorrhage or intraventricular haemorrhage associated with worsening of the NIHSS score by ≥4 within 24 h.

  • IV, intravenous; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; rt-PA, recombinant tissue plasminogen activator; sICH, symptomatic intracranial haemorrhage.