Cut-off values that identify PBVC/y (as measured by SIENA) distinguishing HC from patients with MS with specificity ranging from 95% to 80% and the corresponding levels of sensitivity
| PBVC cut-offs, % | Specificity (%) | Sensitivity (%) |
|---|---|---|
| −0.52 | 95% (observed 97) | 49% (observed 44) |
| −0.46 | 90% (observed 91) | 56% (observed 48) |
| −0.40 | 80% (observed 86) | 65% (observed 61) |
Values of probability are estimated from the theoretical normal distributions of PBVC/y in HC and patients with MS (in brackets, those actually observed are reported). Note that the observed sensitivity was very similar when only patients with RRMS (n=180) were considered.
HC, healthy controls; MS, multiple sclerosis; PBVC/y, annualised percent brain volume change; RRMS, relapsing–remitting multiple sclerosis.