Table 3

Univariate and multivariate Cox-regression analysis for mortality

	Sample, n		Median survival, months		Univariate analysis		Multivariate analysis*
	NIV	No NIV	NIV	No NIV	HR (95% CI)	p Value	HR (95% CI)	p Value
All phenotypes†	219	710	28.63	15.02	0.61 (0.51 to 0.73)	0.000	0.72 (0.60 to 0.88)	0.001
ALS-bulbar‡	58	254	32.61	13.57	0.50 (0.36 to 0.70)	0.000	0.59 (0.41 to 0.83)	0.003
ALS-cervical‡	61	179	27.15	17.55	0.77 (0.55 to 1.06)	0.112	0.89 (0.61 to 1.30)	0.571
ALS-lumbar‡	78	216	27.55	12.23	0.62 (0.45 to 0.84)	0.003	0.71 (0.50 to 1.00)	0.051
Flail limb‡	22	61	55.92	24.92	0.57 (0.31 to 1.05)	0.07	0.72 (0.37 to 1.41)	0.344
All phenotypes†	219	710	28.63	15.02	0.61 (0.51 to 0.73)	0.000	0.72 (0.60 to 0.88)	0.001

*Multivariate model includes the variables: percutaneous endoscopic gastrostomy, riluzole, age of onset and gender.
†Analysis stratified by phenotype and year of index in the database (ie, before 2003 and after 2003).
‡Analysis stratified by year of index in the database (ie, before 2003 and after 2003).
ALS, amyotrophic lateral sclerosis; NIV, non-invasive ventilation.