AED | Number of informative outcomes | Number of MCMs | MCM rate (95% CI) | OR (95% CI) (compared with lowest dose range shown) | p Value (compared with lowest dose range shown) |
---|---|---|---|---|---|
Valproate | 1220 | 82 | 6.7% (5.5% to 8.3%) | ||
0–≤600 mg | 476 | 24 | 5.0% (3.4% to 7.4%) | ||
>600–≤1000 mg | 426 | 26 | 6.1% (4.2% to 8.8%) | 1.24 (0.69 to 2.17) | 0.49 |
>1000 mg | 297 | 31 | 10.4% (7.4% to 14.4%) | 2.20 (1.26 to 3.82) | 0.0045 |
Unknown dose | 21 | 1 | 4.8% (0.9% to 22.7%) | 0.94 (0.12 to 7.31) | 1.00 |
Carbamazepine | 1657 | 43 | 2.6% (1.9% to 3.5%) | ||
0–≤500 mg | 721 | 14 | 1.9% (1.2% to 3.2%) | ||
>500–≤1000 mg | 739 | 20 | 2.7% (1.8% to 4.1%) | 1.41 (0.70 to2.80) | 0.33 |
>1000 mg | 170 | 9 | 5.3% (2.7% to 9.5%) | 2.82 (1.20 to 6.64) | 0.01 |
Unknown dose | 27 | 0 | 0% (0% to 12.5%) | 0.88 (0.05 to 15.27) | 1.00 |
Lamotrigine | 2098 | 49 | 2.3% (1.8% to 3.1%) | ||
0–≤200 mg | 1143 | 24 | 2.1% (1.4% to 3.1%) | ||
>200–≤400 mg | 665 | 16 | 2.4% (1.5% to 4.0%) | 1.15 (0.61 to 2.18) | 0.67 |
>400 mg | 267 | 9 | 3.4% (1.9% to 6.5%) | 1.63 (0.75 to 3.54) | 0.22 |
Unknown dose | 23 | 0 | 0% (0% to 14.3%) | 0.97 (0.06 to 16.48) | 1.00 |
AED, antiepileptic drug; MCM, major congenital malformation.