Bone metabolism and DXA findings of patients with SBMA
| Mean±SD (range; median) | Controls Mean±SD | p Value of patients vs controls | |
|---|---|---|---|
| Bone metabolism analyses | |||
| Serum calcium (mmol/L) (reference range 2.1–2.8) | 2.4±0.1 (2.19–2.69; 2.39) | 2.3±0.1 | ns |
| Serum phosphorus (mmol/L) (reference range 1–1.5) | 0.97±0.14 (0.64–1.29; 0.98) | 1.0±0.2 | ns |
| Alkaline phosphatase (UI/L) (reference range 44–147) | 55.7±16.5 (34–111; 52) | – | – |
| Parathyroid hormone (pg/mL) (reference range 10–60) | 28.7±12.0 (5.8–63; 27.1) | 33.3±15.6 | ns |
| 25-OH vitamin D (nmol/L) (reference range >50) | 43.3±23.0 (8.9–133; 40.84) | 37.6±28.5 | ns |
| DXA parameters | |||
| Lumbar BMD (g/cm2) | 1.19±0.19 (0.79–1.42; 1.14) | 1.08±0.21 | 0.0019 |
| Lumbar T-score | 0.66±1.38 (−1.5–5.2; 0.45) | −0.33±0.95 | 0.0001 |
| Femoral BMD (g/cm2) | 0.97±0.22 (0.26–1.9; 0.95) | 1.02±0.19 | ns |
| Femoral T-score | −0.65±1.16 (−4.31–1.9; −0.6) | −0.41±0.72 | ns |
| Low BMD | Patient number | Control number | p patients vs controls |
| Lumbar level | 1/61 | 6/60 | 0.045 |
| Femoral level | 20/61 | 9/60 | 0.022 |
| Femoral/lumbar level | 4/61 | 3/60 | ns |
BMD, Bone Mineral Density; DXA, dual-energy X-ray absorptiometry; ns, not significant; SBMA, spinal and bulbar muscular atrophy.