Demographic and clinical characteristics of patients at initial presentation
| Clinical characteristics | amnestic AD (n=29) | PCA (n=12) | lvPPA (n=12) | bvFTD (n=20) | nfvPPA (n=7) | svPPA (n=6) | SCI (n=25) |
|---|---|---|---|---|---|---|---|
| Age (years) | 63.9a (8.4) | 61.4 (6.2) | 69.2c (8.7) | 61.7 (8.4) | 67.0 (7.6) | 68.2a (7.6) | 57.4 (7.2) |
| Education (years) | 13.3* (2.7) | 11.9 (1.9) | 12.1 (2.5) | 12.8 (2.6) | 12.7 (2.6) | 12.7 (2.7) | 13.2 (2.8) |
| Symptom duration (years) | 2.3* (1.3) | 2.2 (0.79) | 2.2* (0.85) | 2.6 (2.2) | 2.6 (2.1) | 1.6 (0.77) | 2.8 (2.8) |
| ACE attention and orientation (18) | 12.9d (3.4) | 13.8a (3.9) | 12.4 (5.9) | 14.8 (3.6) | 16.6 (3.1) | 17.8 (0.5) | 17.7 (0.47) |
| ACE memory (26) | 11.6d (4.2) | 16.3b (6.8) | 10.9d (9.2) | 15.1d (6.0) | 19.0 (6.6) | 17.8 (4.2) | 23.5 (3.2) |
| ACE fluency (14) | 6.3d (3.1) | 8.6 (3.8) | 6.0c (4.8) | 5.1d (3.6) | 5.2b (3.8) | 6.5 (1.3) | 11.6 (1.9) |
| ACE language (26) | 22.0a,h (3.8) | 20.3b (4.1) | 15.7d (6.8) | 20.2c (4.9) | 20.8 (4.0) | 16.5b (2.9) | 25.7 (0.66) |
| ACE visuospatial (16) | 11.2d,e (3.9) | 7.6d (4.8) | 12.9f (3.0) | 13.4g (2.9) | 15.8g (0.5) | 15.8g (0.5) | 15.9 (0.49) |
| ACE total (100) | 65.5d* (14.5) | 66.7d (16.5) | 57.6d* (27.0) | 69.0d* (16.2) | 76.8* (15.5) | 74.5* (6.0) | 94.6 (3.3) |
Significant difference compared to aSCI p<0.05; bSCI p<0.01; cSCI p<0.001; dSCI p<0.0001; ePCA p<0.05; fPCA p<0.01; gPCA p<0.0001; hlvPPA p<0.001.
*Missing data: Education level not recorded for 3 patients with amnestic AD; symptom duration not available for 1 lvPPA and 1 patients with amnestic AD as they presented alone; ACE not completed in 2 lvPPA, 1 amnestic AD, 1 bvFTD, 2 nfvPPA and 2 svPPA due to either refusal by patient or clinicians decision not to test due to patient severity/anxiety.
ACE, Addenbrooke's Cognitive Examination; AD, Alzheimer's disease; bvFTD, behavioural variant frontotemporal dementia; lvPPA, logopenic variant primary progressive aphasia; nfvPPA, non-fluent variant primary progressive aphasia; PCA, posterior cortical atrophy; SCI, subjective cognitive impairment; svPPA, semantic variant primary progressive aphasia.