Table 2

Comparison of MRI of 45 children with NMO or limited forms of the disease with MOG-IgG, AQP4-IgG or absent antibodies

MOG-IgG positive (n=25)AQP4-IgG positive (n=5)Seronegative (n=15)p Value
MRI at baseline
 Normal MRI6 (24.0%)0 (0.0%)5 (33.3%)0.012*
 ON3 (12.0%)1 (20.0%)1 (6.7%)
 LETM5 (20.0%)1 (20.0%)7 (46.7%)
 NMO like1 (4.0%)3 (60.0%)0 (0.0%)
 Unspecific lesions1 (4.0%)0 (0.0%)1 (6.7%)
 Blurred+ON or LETM9 (36.0%)0 (0.0%)1 (6.7%)
MRI-ON6 (24.0%)1 (20.0%)1 (6.7%)0.378*
MRI-LETM13 (52.0%)1 (20.0%)8 (53.3%)0.390*
Periependymal2 (8.0%)3 (60.0%)0 (0.0%)0.001*
Blurred lesions9 (36.0%)0 (0.0%)1 (6.7%)0.043*
Unspecific lesions1 (4.0%)3 (60.0%)2 (13.3%)0.004*
MRI at follow-up
MRI follow-up
 BL+FU normal4/15 (26.7%)0/4 (0.0%)4/9 (44.4%)0.246‡
 FU normal6/15 (40.0%)1/4 (25.0%)2/9 (22.2%)
 Mild residuals5/15 (33.3%)1/4 (25.0%)2/9 (22.2%)
 Moderate residuals0/15 (0.0%)1/4 (25.0%)0/9 (0.0%)
 Severe residuals0/15 (0.0%)1/4 (25.0%)1/9 (11.1%)
Moderate/severe MRI residuals0/15 (0.0%)2/4 (50.0%)1/9 (11.1%)0.018‡
  • 2 test.

  • †Median (range), Kruskal-Wallis test.

  • ‡Corrected Fisher's exact contingency table analysis.

  • AQP4, aquaporin-4; BL, baseline; FU, follow-up; LETM, longitudinally extensive transverse myelitis; MOG, myelin oligodendrocyte glycoprotein; NMO, neuromyelitis optica; ON, optic neuritis.