Clinical characteristics of the included patients (n=465)
| Characteristic | |
|---|---|
| Age at onset (years) (mean±SD) | 61.3±11.3 |
| Men/women (n) | 269/196 |
| Initial symptoms (n (%)) | |
| Upper limb weakness | 213 (45.8) |
| Lower limb weakness | 139 (29.9) |
| Bulbar symptoms | 119 (25.5) |
| Neck weakness | 12 (2.6) |
| Use of riluzole (n (%)) | 265 (58.7) |