Univariate analysis of clinical and demographic predictors of NRS IR at T1 in a population of 1432 patients
| Univariate analysis T1 | |||||
|---|---|---|---|---|---|
| IR+ N=1010 | IR− N=422 | OR | 95% CI | p Value | |
| Sex | |||||
| Women (%) | 540 (53.5) | 214 (50.7) | 1 | NA | NA |
| Men (%) | 469 (46.4) | 208 (49.3) | 0.89 | 0.7 to 1.1 | 0.324 |
| Age (years, mean. Median=51) | 50.8±9.6 | 51.2±9.6 | 0.99 | 0.98 to 1.0 | 0.471 |
| 18/51 | 539 (53.4) | 242 (57.3) | 1 | NA | NA |
| 51/99 | 471 (46.6) | 180 (42.6) | 0.98 | 0.78 to 1.23 | 0.893 |
| Disease duration (years, mean. Median=17) | 17.8±8.6 | 17.4±8.6 | 1.0 | 0.99 to 1.01 | 0.416 |
| 0/17 | 518 (51.3) | 212 (50.2) | 1 | NA | NA |
| >17 | 492 (48.7) | 210 (49.8) | 0.93 | 0.74 to 1.17 | 0.552 |
| EDSS (years, mean. Median=6.5) | 6.5±1.1 | 6.5±1.2 | 1.02 | 0.92 to 1.12 | 0.686 |
| 0–6.5 | 607 (60) | 245 (58) | 1 | NA | NA |
| >6.5 | 403 (39.9) | 177 (41.9) | 0.97 | 0.77 to 1.22 | 0.806 |
| Multiple sclerosis type | |||||
| Relapsing remitting | 188 (18.6) | 74 (17.5) | 1 | NA | NA |
| Secondary progressive and primary progressive | 822 (81.4) | 348 (82.4) | 1.4 | 1.05 to 1.86 | 0.018 |
| NRS (score, mean. Median=8) | 7.6±1.4 | 7.3±1.5 | 1.2 | 1.1 to 1.3 | <0.001 |
| 4/8 | 752 (74.5) | 322 (76.3) | 1 | NA | NA |
| >8 | 258 (25.5) | 100 (23.7) | 1.8 | 1.4 to 2.4 | <0.001 |
EDSS, expanding disability status scale; IR, initial response; NA, not applicable; NRS, numerical rating scale.