Table 2

AED responsiveness for the PWMB and CB

IpsilateralContralateral
ParameterROIWell controlledNot well controlledCohen's dp ValueWell controlledNot well controlledCohen's dp Value
Parahippocampal white matter bundle
MD11.29 (0.24)1.31 (0.41)0.0370.9181.33 (0.25)1.41 (0.36)0.2600.491
21.19 (0.17)1.28 (0.27)0.3470.3431.30 (0.18)1.37 (0.30)0.2610.489
31.08 (0.12)1.28 (0.28)0.8940.0191.17 (0.16)1.24 (0.24)0.3470.360
41.07 (0.13)1.27 (0.34)0.7340.0501.08 (0.15)1.12 (0.20)0.2380.529
51.12 (0.19)1.30 (0.34)0.6550.0791.11 (0.18)1.10 (0.20)−0.0480.898
FA10.16 (0.03)0.16 (0.04)−0.1500.6800.16 (0.04)0.15 (0.04)−0.2280.546
20.19 (0.02)0.18 (0.04)−0.3860.2920.18 (0.04)0.18 (0.04)−0.1220.745
30.20 (0.03)0.18 (0.04)−0.5360.1470.20 (0.04)0.19 (0.04)−0.3840.311
40.17 (0.04)0.15 (0.04)−0.5390.1450.20 (0.04)0.18 (0.03)−0.4960.194
50.12 (0.04)0.14 (0.04)0.3370.3560.16 (0.04)0.15 (0.04)−0.1760.641
MK10.75 (0.04)0.75 (0.07)−0.0450.9020.77 (0.04)0.78 (0.08)0.1190.752
20.75 (0.06)0.77 (0.06)0.1900.6010.79 (0.04)0.80 (0.06)0.2100.577
30.73 (0.10)0.76 (0.07)0.3370.3570.78 (0.05)0.81 (0.05)0.4930.196
40.69 (0.09)0.73 (0.09)0.4460.2250.75 (0.05)0.79 (0.09)0.4430.244
50.67 (0.11)0.72 (0.08)0.6040.1040.73 (0.06)0.75 (0.09)0.2530.503
KFA10.22 (0.08)0.23 (0.09)0.0380.9160.21 (0.09)0.19 (0.10)−0.2330.537
20.25 (0.08)0.23 (0.08)−0.2930.4210.22 (0.07)0.20 (0.08)−0.1880.617
30.30 (0.08)0.23 (0.09)−0.7780.0390.26 (0.07)0.23 (0.09)−0.3620.340
40.29 (0.09)0.22 (0.10)−0.7390.0490.31 (0.09)0.26 (0.09)−0.5020.189
50.24 (0.10)0.20 (0.08)−0.5250.1550.26 (0.08)0.26 (0.09)0.0220.952
Cingulum bundle
MD10.91 (0.06)0.96 (0.06)0.7240.0530.94 (0.08)0.95 (0.08)0.1550.669
20.88 (0.07)0.92 (0.08)0.6460.0830.90 (0.08)0.92 (0.07)0.2960.417
30.85 (0.06)0.89 (0.07)0.6290.0910.89 (0.09)0.90 (0.07)0.1450.690
40.85 (0.06)0.90 (0.09)0.6680.0730.87 (0.09)0.90 (0.10)0.3290.369
50.84 (0.05)0.89 (0.08)0.7730.0400.84 (0.07)0.90 (0.13)0.5790.118
FA10.21 (0.05)0.18 (0.04)−0.7920.0360.17 (0.04)0.16 (0.03)−0.2610.474
20.29 (0.06)0.23 (0.07)−1.0320.0070.22 (0.05)0.22 (0.05)−0.0890.807
30.36 (0.06)0.29 (0.06)−1.1530.0030.27 (0.07)0.27 (0.07)−0.0470.896
40.35 (0.05)0.31 (0.07)−0.7900.0360.30 (0.09)0.27 (0.06)−0.4450.226
50.31 (0.06)0.26 (0.06)−0.8060.0330.28 (0.08)0.23 (0.06)−0.6280.091
MK10.83 (0.07)0.85 (0.06)0.2890.4280.81 (0.08)0.83 (0.07)0.2410.507
20.83 (0.09)0.88 (0.09)0.5110.1660.81 (0.08)0.87 (0.09)0.7520.045
30.86 (0.13)0.91 (0.10)0.4260.2460.83 (0.10)0.90 (0.10)0.6890.065
40.87 (0.10)0.92 (0.09)0.5020.1730.84 (0.09)0.89 (0.10)0.5340.148
50.86 (0.12)0.90 (0.09)0.4430.2280.83 (0.10)0.89 (0.09)0.6310.090
KFA10.45 (0.08)0.37 (0.08)−1.0310.0080.38 (0.06)0.34 (0.08)−0.5510.136
20.57 (0.09)0.45 (0.10)−1.2620.0010.49 (0.10)0.42 (0.10)−0.5940.109
30.63 (0.10)0.53 (0.09)−1.1020.0050.53 (0.12)0.49 (0.10)−0.4330.239
40.59 (0.09)0.49 (0.10)−1.0550.0060.52 (0.13)0.47 (0.11)−0.4370.234
50.50 (0.11)0.40 (0.09)−0.9270.0150.46 (0.12)0.37 (0.11)−0.7760.039
  • Group-wise comparisons were made between subjects whose seizures are well controlled with AEDs (n=13) and subjects whose seizures are not well controlled with AEDs (n=19). Differences with p<0.05 (uncorrected) are indicated by bold font. These may be regarded as trends, as no differences were significant after correcting for multiple comparisons.

  • AED, antiepileptic drug; CB, cingulum bundle; FA, fractional anisotropy; KFA, kurtosis fractional anisotropy; MD, mean diffusivity; MK, mean kurtosis; PWMB, parahippocampal white matter bundle; ROI, region of interest.