Seven top non-HLA-SNPs and their associations with the hazard of conversion to MS and relapse*
| SNP | Chromosome | Gene† | MS | Relapse | ||
|---|---|---|---|---|---|---|
| Number of MS (%) | HR (95% CI) | Number of relapses (%) | HR (95% CI) | |||
| rs12599600‡,§ | 16 | RMI2, PRM1 | ||||
| CA+AA | 25 (36.76) | 1.00 (Reference) | 44 (29.14) | 1.00 (Reference) | ||
| CC¶ | 43 (63.24) | 2.43 (1.43 to 4.10) | 107 (70.86) | 1.85 (1.15 to 2.98) | ||
| Trend | p=0.001 | p=0.011 | ||||
| rs1021156 | 8 | ZC2HC1A, PKIA | ||||
| CC | 33 (48.53) | 1.00 (Reference) | 69 (45.70) | 1.00 (Reference) | ||
| CT¶ | 28 (41.18) | 1.44 (0.86 to 2.42) | 59 (39.07) | 1.22 (0.77 to 1.95) | ||
| TT¶ | 7 (10.29) | 3.56 (1.96 to 6.48) | 23 (15.23) | 2.41 (1.46 to 3.97) | ||
| Trend | p=0.003 | p=0.015 | ||||
| rs694739§ | 11 | PRDX5, CCDC88B | ||||
| GG | 5 (7.35) | 1.00 (Reference) | 16 (10.60) | 1.00 (Reference) | ||
| AG | 32 (47.06) | 2.03 (0.82 to 5.02) | 66 (43.71) | 1.09 (0.45 to 2.65) | ||
| AA¶ | 31 (45.59) | 2.93 (1.21 to 7.09) | 69 (45.70) | 1.40 (0.57 to 3.45) | ||
| Trend | p=0.012 | p=0.310 | ||||
| rs802734 | 6 | PTPRK, THEMIS | ||||
| AA | 31 (45.59) | 1.00 (Reference) | 72 (47.68) | 1.00 (Reference) | ||
| AG | 25 (36.76) | 0.89 (0.52 to 1.51) | 49 (32.45) | 0.78 (0.47 to 1.28) | ||
| GG¶ | 12 (17.65) | 3.97 (1.83 to 8.62) | 30 (19.87) | 1.61 (0.96 to 2.69) | ||
| Trend | p=0.034 | p=0.420 | ||||
| rs1323292‡ | 1 | RGS1, RGS21 | ||||
| AA | 41 (60.29) | 1.00 (Reference) | 88 (58.28) | 1.00 (Reference) | ||
| AG¶+GG¶ | 27 (39.71) | 1.71 (1.03 to 2.84) | 63 (41.72) | 1.41 (0.91 to 2.20) | ||
| Trend | p=0.039 | p=0.130 | ||||
| rs35929052‡,§,** | 16 | IRF8, LOC14651 | ||||
| CT | 11 (16.18) | 1.00 (Reference) | 14 (9.27) | 1.00 (Reference) | ||
| CC¶ | 3 | 57 (83.82) | 1.21 (0.65 to 2.25) | 137 (90.73) | 2.05 (1.27 to 3.30) | |
| Trend | p=0.550 | p=0.003 | ||||
| rs62023605‡ | 16 | CLEC16A, | ||||
| AA | SOCS1 | 39 (57.35) | 1.00 (Reference) | 71 (47.02) | 1.00 (Reference) | |
| AC¶+CC¶ | 29 (42.65) | 1.55 (0.94 to 2.54) | 80 (52.98) | 1.78 (1.18 to 2.68) | ||
| Trend | p=0.080 | p=0.006 | ||||
Results in bold denote statistically significant results (p<0.05).
*Adjusted for age, sex and study recruitment centre, before adjustment for multiple comparisons.
†Provide nearest two genes for intergenic SNPs.
‡The homozygous genotypes were combined with the heterozygous ones due to small numbers.
§For consistency, non-risk alleles was always set as reference.
¶Risk genotype for CGRS.
**No persons had the TT genotype.
CGRS, cumulative genetic risk score; HLA, human leucocyte antigen; MS, clinically definite multiple sclerosis; SNPs, single nucleotide polymorphisms.