Table 5

Combined intervention (CSP–RYCT) versus TAU: adjusted means and differences when main effect or interaction was significant at 12 months

		First follow-up						Second follow-up
Measure	Data set	Missing	Combined	TAU	MD	95% CI of MD	Significance level	Missing	Combined	TAU	MD	95% CI of MD	Significance level
Carer QCPR absence of criticism and conflict*	Original	8	22.28	21.59	0.69	(−0.72 to 2.10)	0.34	14	22.39	20.76	1.63	(0.10 to 3.15)	0.04
Carer QCPR absence of criticism and conflict*	Imputed	0	21.97	21.09	0.88	(−0.85 to 2.34)	0.24	0	22.32	20.21	2.11	(0.54 to 3.69)	0.01
Carer QCPR total*	Original	8	55.57	53.43	2.14	(−0.22 to 4.50)	0.08	14	54.35	51.77	2.59	(−0.27 to 5.44)	0.08
Carer QCPR total*	Imputed	0	54.98	52.51	2.47	(−0.02 to 4.97)	0.05	0	54.20	51.08	3.13	(0.42 to 5.83)	0.03
QoL-AD proxy*†	Original	7	30.73	31.42	−0.69	(−2.34 to 0.96)	0.41	12	29.68	29.88	−0.20	(−2.15 to 1.75)	0.84
QoL-AD proxy*†	Imputed	0	30.49	31.22	−0.73	(−2.40 to 0.94)	0.39	0	29.68	29.88	−0.20	(−2.15 to 1.75)	0.84
DEMQOL proxy*†	Original	7	96.37	100.70	−4.31	(−8.19 to −0.44)	*0.03*	12	95.09	97.40	−2.31	(−6.57 to 1.94)	0.28
DEMQOL proxy*†	Imputed	0	95.67	99.90	−4.23	(−9.08 to −0.38)	*0.03*	0	94.20	96.67	−2.48	(−6.98 to 2.02)	0.28
ADCS-ADL*†	Original	23	42.53	43.18	−0.65	(−4.70 to 3.39)	0.75	35	39.49	44.07	−4.58	(−9.29 to 0.13)	0.06
ADCS-ADL*†	Imputed	0	39.16	40.62	−1.46	(−5.47 to 2.54)	0.48	0	34.02	38.40	−4.39	(−10.20 to 1.43)	0.14

Covariates: baseline score, participant gender, kinship and centre (random effect).
*Higher scores are better.
†MMSE was also covariate in models for people with dementia.
ADCS-ADL, Alzheimer's Disease Cooperative Study—Activities of Daily Living; DEMQOL, quality of life for people with dementia; MMSE, mini-mental state examination; QCPR, Quality of Caregiver–Patient Relationship; QoL-AD, Quality of Life in Alzheimer's Disease Scale.