Cumulative risk of disability for the seven SNPs that predicted ΔEDSS
| Number of 5-year disability measures | β (95% CI) | p Value | R2 | |
|---|---|---|---|---|
| ≤2 risk genotypes* | 21 | 0.14 (0.07 to 0.22) | 0.327 | |
| 3 risk genotypes | 39 | +0.12 (0.02 to 0.22) | 0.024 | |
| 4 risk genotypes | 29 | +0.20 (0.09 to 0.31) | 6.80×10−4 | |
| 5 risk genotypes | 26 | +0.28 (0.17 to 0.40) | 5.14×10−6 | |
| ≥6 risk genotypes† | 10 | +0.48 (0.30 to 0.66) | 8.36×10−8 ptrend=1.53×10−9 |
p: adjusted for age, sex and study recruitment centre; ΔEDSS: annualised change in EDSS.
Disability results presented as geometric mean ΔEDSS (95% CI) for the reference group, and coefficient relative to the reference (β (95% CI)) for subsequent levels.
Results in bold denote statistically significant results (p<0.05).
*No participants carried zero risk genotypes, 5 participants carried one risk genotypes, and 16 carried two risk genotypes.
†No participants carried seven risk genotypes, while 10 participants carried six risk genotypes.
EDSS, Expanded Disability Status Scale; SNPs, single nucleotide polymorphisms.