Comparison of PISTE with published MT trials
| PISTE | MR CLEAN | ESCAPE | EXTEND IA | SWIFT Prime | REVASCAT | |
|---|---|---|---|---|---|---|
| n | 65 | 500 | 315 | 70 | 196 | 206 |
| Key process times (MT arm), min, median | ||||||
| Onset to IVT | 120 | 85 | 110 | 127 | 110 | 117 |
| Onset to randomisation | 150 | 204 | 169 | 156 | 191 | 223 |
| Onset to groin puncture | 209 | 260 | 208 | 210 | 224 | 269 |
| Onset to reperfusion | 259 | 332 | 241 | 248 | 229* | 355 |
| TICI 2b-3 | 87% | 59% | 72% | 86% | 88% | 66% |
| Absolute effect size | ||||||
| mRS 0–1 at day 90 | 24% | 6% | 19% | 23% | 22% | 12% |
| mRS 0–2 at day 90 | 14% | 14% | 25% | 31% | 24% | 15.5% |
| mRS 5–6 | 2% | −7% | −14% | −23% | −17% | −6% |
| Mortality | 9% | −1% | −9% | −11% | −4% | 3% |
*Estimated from interval times reported, but total times not reported.
IVT, intravenous thrombolysis; mRS, modified Rankin Scale; MT, mechanical thrombectomy; TICI, Thrombolysis in Cerebral Infarction.