Novel SNPs showing association with FTD at conditional FDR<0.05
| SNP | Position | Chr | Nearest gene | Reference allele | Associated phenotype | Min Cond FDR | IFGC phase I p-value | IFGC phase I OR (95% CI) | IFGC phase II p-value | IFGC phase II OR (95% CI) | Meta-analysis p-value | Meta-analysis OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs4417745 | 241 225 364 | 2 | Intergenic; OTOS | A | PD | 2.73E−02 | 2.52E−05 | 1.36 (1.18–1.57) | 0.47 | 1.06 (0.90–1.25) | 3.20E−04 | 1.22 (1.09–1.36) |
| rs7664889 | 77 087 704 | 4 | Intronic; SCARB2 | T | PD | 3.23E−02 | 1.75E−04 | 0.73 (0.62–0.86) | 0.82 | 0.98 (0.81–1.18) | 3.18E−03 | 0.83 (0.73–0.94) |
| rs676768 | 116 030 773 | 10 | Intronic; VWA2# | T | PD | 4.25E−02 | 3.12E−04 | 0.78 (0.68–0.90) | 0.55 | 0.96 (0.82–1.11) | 2.40E−03 | 0.86 (0.78–0.95) |
| rs1328032 | 71 420 424 | 13 | Intergenic; DACH1 | A | AD | 1.38E−02 | 1.93E−07 | 0.67 (0.57–0.78) | 0.34 | 0.94 (0.83–1.06) | 7.39E−05 | 0.80 (0.72–0.88) |
| rs2446406 | 51 679 783 | 15 | Intronic; GLDN# | A | PD | 2.59E−02 | 7.18E−07 | 0.81 (0.74–0.88) | 0.40 | 0.96 (0.87–1.06) | 2.24E−05 | 0.87 (0.82–0.93) |
| rs7184882 | 73 737 373 | 16 | In orf; LOC101927998 | T | AD | 4.24E−02 | 6.64E−07 | 0.71 (0.62–0.81) | 0.08 | 0.89 (0.78–1.02) | 3.08E−06 | 0.78 (0.71–0.86) |
| rs199528 | 44 843 136 | 17 | Intronic; WNT3 | T | PD | 1.79E−02 | 4.09E−05 | 0.82 (0.74–0.90) | 0.03 | 0.89 (0.80–0.99) | 9.59E−06 | 0.85 (0.79–0.91) |
| rs1358071 | 43 803 189 | 17 | Intronic; CRHR1 | A | PD | 2.01E−02 | 4.96E−05 | 1.22 (1.12–1.31) | 0.001 | 1.16 (1.07–1.26) | 4.91E−07 | 1.19 (1.11–1.27) |
| rs12964543 | 56 543 095 | 18 | Intronic; ZNF532# | A | PD | 2.71E−02 | 1.12E−04 | 1.24 (1.11–1.38) | 0.24 | 1.05 (0.96–1.15) | 9.10E−04 | 1.12 (1.05–1.2) |
| rs6857 | 45 392 254 | 19 | 3′-UTR; PVRL2# | T | PD | 4.69E−02 | 7.03E−07 | 1.31 (1.18–1.46) | 4.46E−07 | 1.37 (1.21–1.55) | 2.21E−12 | 1.34 (1.23–1.45) |
| rs405509 | 45 408 836 | 19 | Intergenic; APOE | T | AD | 5.26E−03 | 1.25E−05 | 1.18 (1.09–1.27) | 0.93 | 1.0 (0.92–1.09) | 5.98E−05 | 1.15 (1.08–1.24) |
ORs provided for the reference allele.
# rs676768 not available, proxy SNP rs12782946 from IFGC phase II.
# rs2446406 not available, proxy SNP rs2445742 from IFGC phase II.
# rs12964543 not available, proxy SNP exm2272683 from IFGC phase II.
# rs6857 not available, proxy SNP rs2075650 from IFGC phase II.
AD, Alzheimer's disease; FDR, false discovery rate; FTD, frontotemporal dementia; IFGC, International FTD-Genomics Consortium; PD, Parkinson's disease.