Table 1

Demographic, intermediate marker and risk information on higher and lower risk participants seen in person compared with those that were not seen

Higher risk seenHigher risk not seenp ValueLower risk seenLower risk not seenp Value
n7475111770
Age (95% CI)72.2 (69.0 to 75.5)70.8 (68.1 to 74.0)0.25264.9 (62.8 to 66.6)67.1 (64.9 to 70.6)<0.001
Male gender (%)63 (85.1)54 (72.0)0.07231 (27.9)243 (31.6)0.511
First-degree relative (%)36 (48.6)22 (29.3)0.0199 (8.1)107 (13.9)0.100
Current smoker (%)1 (1.4)0 (0)0.49711 (9.9)17 (2.2)<0.001
Past smoker (%)38 (51.4)31 (41.3)0.25251 (45.9)293 (38.1)0.119
Diabetes mellitus (%)8 (10.8)4 (5.3)0.2458 (7.2)33 (4.3)0.222
High cholesterol (%)33 (44.6)31 (41.3)0.74235 (31.5)213 (27.7)0.430
Ischaemic Heart disease (%)13 (17.6)11 (14.7)0.6623 (2.7)31 (4)0.791
Hypertension (%)34 (45.9)27 (36)0.24640 (36)228 (29.6)0.186
Drink coffee (%)65 (87.8)71 (94.7)0.159108 (97.3)694 (90.1)0.012
Drink alcohol (%)67 (90.5)66 (88)0.792101 (91)674 (87.5)0.351
Constipation (%)22 (29.7)29 (38.7)0.30117 (15.3)113 (14.7)0.776
Anxiety/depression (%)14 (18.9)15 (20)0.99913 (11.7)87 (11.3)0.873
Head injury (%)36 (48.6)36 (48)0.99926 (23.4)218 (28.3)0.309
Hyposmia ≤27/40 on UPSIT (109 available)13 of 56 (23.2%)16 of 53 (30.2%)0.666(653 available)8 of 88 (9.1%)76 of 565 (13.3%)0.307
Subjective RBD ≥5 on RBDSQ (147 available)18 of 75 (24.0%)10 of 72 (13.8%)0.141(880 available)14 of 112 (12.5%)81 of 768 (10.5%)0.513
Slow finger tapping KS ≤44 taps in 30 s (124 available)21 of 67 (31.3%)12 of 57 (21.1%)0.161(749 available)12 of 92 (13.0%)100 of 657 (15.2%)0.754
Risk estimate year 1 (IQR)9.9 (6.9–15.1)15.3 (12.3–18.2)<0.001136.8 (54.3–207.3)78.1 (48.2–118.7)<0.001
Rank year 1 (IQR)54 (25–100)103 (71–133)<0.001860 (424–1001)580 (373–784)<0.001
  • Information from survey answers in year 1. Hypertension defined according to self-report or use of diuretics, ACE inhibitors and angiotensin receptor blocking drugs, calcium channel blockers, and beta blockers (including propranolol, atenolol, bisoprolol, but not sotalol or timolol). High cholesterol defined according to self-report or statin use. Diabetes mellitus defined according to self-report or use of metformin, gliclazide or insulin.

  • UPSIT, University of Pennsylvania Smell Identification Test; RBDSQ, RBD screening questionnaire; KS, kinesia score.