Table 3

Overview of RCTs in children

StudyNumber of patientsDesignInclusion criteriaResults
Gürses et al 19954418Single centre quasi-randomised parallel group
Supportive care vs 2 g/kg IVIG over 2 days
Resembling GBS criteria of Asbury 1990The interval from onset to nadir, from nadir to improvement and duration of hospitalisation was significantly shorter in the IVIg group than in the controls.
Wang et al 20014654Single centre parallel group
Dexamethasone alone vs dexamethasone and IVIg (0.2 to 0.3 g/kg daily for 5–6 days) vs dexamethasone and PE
UnknownSignificant earlier and better recovery in IVIg + dexamethasone group compared with dexamethasone alone and the PE group
Korinthenberg et al 20052621Multicentre randomised parallel group
Supportive care vs IVIg (1 g/kg over 2 days)
Children able to walk without aid for ≥5 mNo difference in maximum disability grade but significantly earlier onset of improvement and lower GBS disability grade at 4 weeks
51Multicentre randomised parallel group
IVIg 2 g/kg over 2 days vs 2 g/kg over 5 days
Children unable to walk 5 m unaidedNo differences in both primary and secondary outcome measures but more often TRFs observed in short regimen group
El-Bayoumi et al 20114541Single centre randomised parallel groupIVIg (2 g/kg over 5 days) vs PEChildren who were ventilatedChildren treated with PE had slightly but significant shorter time of mechanical ventilation
  • GBS, Guillain-Barré syndrome; IVIg, intravenous immunoglobulin; PE, plasma exchange; RCT, randomised controlled trial; TRFs, treatment-related fluctuations.