Comparisons of pathological parameters among anti-neurofascin-155 antibody-positive patients, antibody-negative patients and normal controls
| Probability | ||||||
|---|---|---|---|---|---|---|
| 1. Anti-neurofascin-155 antibody-positive patients n=9 | 2. Antibody-negative patients n=13 | 3. Normal controls* n=10 | 1 vs 2 | 1 vs 3 | 2 vs 3 | |
| Nerve fibre density (number/mm2) | ||||||
| Myelinated fibres | 6594±985 | 5948±1516 | 8887±1330 | NS | <0.01 | <0.0001 |
| Unmyelinated fibres | 30 298±4794 | 26 881±5221 | 30 586±4376 | NS | NS | NS |
| Teased-fibre study (%) | ||||||
| Demyelination | 1.3±3.0 | 4.1±4.6 | 0 | NS | NS | <0.05 |
| Remyelination | 3.6±2.6 | 13.7±12.3 | 4.3±4.5 | <0.01 | NS | <0.05 |
| Axonal degeneration | 3.6±4.2 | 1.4±1.9 | 0.6±0.7 | NS | <0.05 | NS |
| Axo–glial detachment (%) | 53.5±25.5 | 3.4±3.7 | <0.001 | |||
Values are expressed as the mean±SD.
Probability was determined with the Mann-Whitney U test.
*Normal control values were obtained from 10 autopsy cases in which the patients died of non-neurological diseases (36.8±19.1 years of age, mean±SD; three men, seven women).
NS, not significant.