Statistically significant within-group grey matter volume associations with clinical measures of interest for the entire cohort (N=23) and for the subset of women with functional neurological disorder (N=18)
| n | Measures of interest |
Cerebral regions (Brodmann area) | Peak coordinates in MNI space (mm) |
Peak voxel
z-score |
p Value
(SVC) |
Cluster extent
(mm3) | ||
| x | y | z | ||||||
| 23 | PTSD-Hyperarousal | Dorsal ACC (24) | 0 | 30 | 24 | −3.97 | <0.001 (0.014) | 229 |
| LEC—happened to me | L hippocampus (20) | −33 | −27 | −12 | −4.01 | <0.001 (0.010) | 176 | |
| 18 | PHQ-15 | L anterior insula (48) | −40 | 12 | −11 | −3.93 | <0.001 (0.032) | 169 |
| SOMS:CD | L anterior insula (48) | −42 | 9 | −12 | −3.87 | <0.001 (0.038) | 53 | |
| CTQ-Abuse | L anterior insula (48) | −39 | 9 | −12 | −4.04 | <0.001 (0.021) | 156 | |
| PTSD-Avoidance | R dorsal/perigenual ACC (24) | 2 | 32 | 24 | −3.66 | <0.001 (0.046) | 86 | |
| LEC—happened to me | L hippocampus (20) | −33 | −27 | −12 | −4.27 | <0.001 (0.005) | 230 | |
Small-volume corrected (SVC) findings are listed in parentheses. ACC, anterior cingulate cortex; CTQ, Childhood Trauma Questionnaire, LEC, Life Events Checklist; MNI, Montreal Neurological Institute; PHQ-15, Patient Health Questionnaire-15; PTSD, post-traumatic stress disorder; SOMS:CD, Conversion Disorder subscale of the Screening for Somatoform Symptoms-7 scale. PTSD subscores are based on the PTSD Checklist for DSM-5.