Demographics, lesion details and baseline behavioural performance of the patients with aphasic stroke
| ID | Group | Sex | Hand- edness | Severity | Aphasia subtype | Age at baseline (years) | Time since stroke (years) | Type of stroke | Lesion volume (cm3) | % of ROI damaged | Speech comprehension | Speech production | ||||
| Left A1 | Left STG | CAT word comp. (/30) | CAT sentence comp. (/32) | Vowel ID (/40) | CAT repetition (/74) | CAT object naming (/48) | ||||||||||
| 1 | 1 | M | L | M | G | 69.6 | 1.0 | I | 69.5 | 1.8 | 0.0 | 29 | 28 | 27 | 28 | 6 |
| 2 | 2 | M | R | M | W | 62.7 | 1.2 | I | 42.4 | 7.2 | 21.1 | 30 | 22 | 38 | 34 | 38 |
| 3 | 1 | M | R | M | W | 63 | 8.6 | I | 429.3 | 81.0 | 43.3 | 27 | 21 | 17 | 50 | 22 |
| 4 | 1 | M | L | M | W | 61.5 | 7.6 | I | 314.0 | 52.9 | 0.0 | 23 | 25 | 16 | 38 | 12 |
| 5 | 1 | M | R | M | W | 67.8 | 7.4 | H | 64.3 | 8.1 | 30.5 | 29 | 21 | 37 | 50 | 30 |
| 6 | 2 | M | R | M | W | 60.5 | 5.6 | I | 161.1 | 52.7 | 9.3 | 27 | 30 | 34 | 54 | 27 |
| 7 | 1 | M | R | M | W | 64.9 | 1.2 | I | 171.1 | 39.7 | 17.9 | 27 | 21 | 38 | 60 | 33 |
| 8 | 1 | M | R | S | G | 61.4 | 1.9 | I | 242.9 | 52.6 | 52.6 | 24 | 6 | 16 | 0 | 0 |
| 9 | 2 | F | R | S | G | 66.5 | 5.3 | I | 195.2 | 42.3 | 21.4 | 21 | 15 | 13 | 23 | 12 |
| 10 | 1 | M | R | M | W | 61.5 | 3.4 | M-L* | 1.6 | 0.0 | 0.0 | 26 | 26 | 40 | 63 | 36 |
| 11 | 1 | M | R | S | G | 63.3 | 0.6 | I | 69.0 | 8.3 | 33.5 | 20 | 13 | 12 | 0 | 0 |
| 12 | 2 | F | R | S | G | 43.5 | 1.3 | I | 69.7 | 68.7 | 46.1 | 14 | 17 | 17 | 18 | 14 |
| 13 | 2 | F | R | S | W | 46.3 | 0.7 | I | 31.7 | 60.9 | 15.3 | 26 | 12 | 26 | 26 | 41 |
| 14 | 2 | M | R | S | G | 71.1 | 5.1 | I | 151.1 | 79.5 | 29.8 | 20 | 14 | 7 | 0 | 0 |
| 15 | 2 | M | R | S | G | 62.4 | 3.7 | I | 168.6 | 20.2 | 0.0 | 22 | 11 | 21 | 30 | 0 |
| 16 | 1 | M | R | M | W | 60.9 | 3.0 | H | 136.6 | 11.7 | 1.5 | 28 | 26 | 40 | 68 | 37 |
| 17 | 1† | M | R | M | G | 45.4 | 3.7 | I | 61.2 | 5.8 | 16.7 | 27 | 21 | 39 | 31 | 18 |
| 18 | 2 | M | R | M | W | 74.7 | 0.6 | I | 41.1 | 7.3 | 2.9 | 24 | 26 | 24 | 45 | 14 |
| 19 | 2 | M | R | M | G | 50.2 | 1.8 | I | 280.5 | 29.5 | 0.9 | 25 | 26 | 39 | 28 | 2 |
| 20 | 1 | M | R | M | W | 90.3 | 3.7 | I | 62.9 | 14.2 | 0.0 | 27 | 21 | 34 | 68 | 43 |
Behavioural measures included CAT spoken word comprehension (score cut-off for impaired performance=25), CAT spoken sentence comprehension (cut-off=27), vowel identification (36), CAT total repetition score (67) and CAT object naming (43). Values highlighted in bold indicate scores below the threshold for normal performance.
*Patient 10 had four small lacunes in the left hemisphere: (1) superior and lateral occipital lobe (I); (2) deep to the superior frontal sulcus (I); (3) superior longitudinal fasciculus (L) and (4) inferomedial thalamus (L).
†Patient 17 failed to escalate to 10 mg of donepezil in the second drug block and remained on 5 mg for both blocks.
CAT, comprehensive aphasia test; I, infarct; H, haemorrhagic; M-L, multilacune; ROI, region of interest; STG, superior temporal gyrus.