Pooled mutated rate, heterogeneity statistics and linear regression test of funnel plot asymmetry of major ALS-related genes
| FALS | SALS | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Studies | Cases | Mutation rate (95% CI) | Q | p (Q) | I2(%) | pf Value | Studies | Cases | Mutation rate (95% CI) | Q | p (Q) | I2 (%) | pf Value |
| SOD1 | 48 | 2634 | 0.189 (0.154 to 0.226) | 217.56 | <0.0001 | 78 | 0.03 | 36 | 7811 | 0.012 (0.008 to 0.018) | 128.78 | <0.0001 | 73 | 0.22 |
| TARDBP | 26 | 1267 | 0.033 (0.014 to 0.060) | 120.64 | <0.0001 | 79 | 0.09 | 40 | 10 681 | 0.005 (0.002 to 0.009) | 317.40 | <0.0001 | 88 | 0.46 |
| FUS | 29 | 2107 | 0.030 (0.023 to 0.038) | 49.62 | 0.007 | 44 | 0.83 | 26 | 10 877 | 0.004 (0.002 to 0.006) | 60.88 | <0.0001 | 59 | 0.87 |
| C9orf72 | 33 | 2630 | 0.225 (0.171 to 0.283) | 337.06 | <0.0001 | 91 | 0.004 | 36 | 18 175 | 0.031 (0.021 to 0.042) | 517.90 | <0.0001 | 95 | 0.05 |
ALS, amyotrophic lateral sclerosis; FALS, familial amyotrophic lateral sclerosis; I2, percentage of heterogeneity caused by study differences; pf, p value for linear regression test of funnel plot asymmetry; p (Q), p value for heterogeneity; Q, heterogeneity between studies reporting mutations in major ALS-related genes; SALS, sporadic amyotrophic lateral sclerosis.