Table 2

Univariate and multivariate meta-regression analyses of potential sources of heterogeneity in the mutation rate of major ALS-related genes

	p Value in FALS				p Value in SALS
Heterogeneity factors	SOD1	TARDBP	FUS	C9orf72	SOD1	TARDBP	FUS	C9orf72
Population
Univariate	<0.0001	0.28	<0.05	<0.0001	0.78	0.05	0.06	<0.0001
Multivariate	<0.0001	0.75	0.04	<0.0001	0.65	0.08	0.12	<0.0001
Study design
Univariate	0.0003	0.85	0.48	0.03	0.40	0.84	0.34	0.35
Multivariate	0.005	0.84	0.82	0.23	0.55	0.99	0.85	0.58
Sequencing method
Univariate	0.94	0.15	0.69	–	0.34	0.65	0.85	–
Multivariate	0.42	0.23	0.44	–	0.31	0.99	0.37	–
Selected screening
Univariate	–	0.06	0.90	–	–	0.23	0.09	–
Multivariate	–	0.11	0.90	–	–	0.30	0.15	–

ALS, amyotrophic lateral sclerosis; FALS, familial amyotrophic lateral sclerosis; SALS, sporadic amyotrophic lateral sclerosis.