Neuropsychiatric disorder | Principal presenting symptoms | Treatment |
Depression |
| SSRIs are first line (fluoxetine, sertraline) TCAs—desipramine SNRIs especially if comorbid pain (venlafaxine, duloxetine) Mirtazapine (less sexual dysfunction) Psychotherapy—CBT, supportive, mindfulness, IPT, exercise and relaxation techniques Lithium augmentation (diuresis and polyuria may be issues) ECT for treatment-resistant cases but may increase risk of MS relapse |
Bipolar disorder |
| Lithium (risk of diuresis) Sodium valproate mania with psychotic symptoms—risperidone, quetiapine, olanzapine, ziprasidone If steroid-induced mania, consider lithium, phenytoin, olanzapine and/or reduced dose of steroids |
Psychosis |
| Atypical antipsychotics
Benzodiazepines (may help sedation but may worsen cognitive impairment) |
Anxiety disorders |
| SSRIs are first-line agents Other options include
|
Substance misuse |
| Counselling services appropriate for the substance of misuse Consider anticraving agents such as acamprosate |
Pseudobulbar affect and euphoria |
| TCAs (amitriptyline, desipramine, nortriptyline) SSRIs Levodopa Amantadine Dextromethorphan and quinidine |
B-FS, Beck Fast Screen for Depression in Medically Ill Patients; CBT, cognitive behavioural therapy; CNS-LS, Center for Neurologic Study-Lability Scale; GAD, generalized anxiety disorder; HADS, Hospital Anxiety and Depression Scale; IPT, interpersonal therapy; MS, multiple sclerosis; NARI, noradrenaline reuptake inhibitor; NaSSA, noradrenergic and specific serotonergic antidepressant; NMDA, N-Methyl-D-aspartate; SNRI, serotonin noradrenergic reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.