Results of the ALE meta-analysis
| Disease group | Cluster size (mm3) | Extent and centre (MNI) | Local extrema (MNI) | p Value | Label |
| AD | |||||
| Cluster 1 | 1016 | (26 -78 -40) to (42 -58 -24) centred at (31 -66 -33) | 30 -68 -38 | 0.014 | R posterior lobe, tonsil |
| 34 -60 -26 | 0.011 | R anterior lobe, culmen | |||
| 28 -70 -28 | 0.009 | R posterior lobe, uvula | |||
| 28 -76 -26 | 0.009 | R posterior lobe, uvula | |||
| ALS | |||||
| Cluster 1 | 648 | (-34 -80 -52) to (-26 -72 -44) centred at (-30 -76 48) | -30 -76 -48 | 0.009 | L posterior lobe, inferior semi-lunar lobule |
| Cluster 2 | 496 | (12 -66 -62) to (20 -58 -54) centred at (16 -62 -58) | 16 -62 -58 | 0.009 | No GM found |
| Cluster 3 | 456 | (6 -60 -18) to (14 -52 -10) centred at (10 -56 -14) | 10 -56 -14 | 0.008 | R anterior lobe, culmen |
| Cluster 4 | 448 | (-8 -72 -30) to (-2 -66 -24) centred at (-5 -69 -27) | -4 -68 -26 | 0.008 | L anterior lobe, nodule |
| FTD | |||||
| Cluster 1 | 1 736 | (-56 -78 -48) to (-30 -56 -34) centred at (-43 -70 -40) | -46 -72 -40 | 0.011 | L posterior lobe, inferior semi-lunar lobule |
| -34 -66 -40 | 0.010 | L posterior lobe, tonsil | |||
| -54-76 -36 | 0.010 | L posterior lobe, pyramis | |||
| -38 -68 -42 | 0.010 | L posterior lobe, tonsil | |||
| -52 -74 -48 | 0.008 | L posterior lobe, inferior semi-lunar lobule | |||
| -38 -60 -42 | 0.008 | L posterior lobe, tonsil | |||
| Cluster 2 | 728 | (38 -68 -50) to (50 -56 -40) centred at (42 -61 -45) | 42 -60 -44 | 0.013 | R posterior lobe, tonsil |
| 48 -66 -48 | 0.008 | R posterior lobe, tonsil | |||
| Cluster 3 | 640 | (46 -72 -36) to (54 -64 -20) centred at (50 -68 -27) | 52 -68 -28 | 0.011 | R posterior lobe, tuber |
| 50,-68,-24 | 0.010 | R posterior lobe, declive | |||
| HD | No clusters found | ||||
| MSA | |||||
| Cluster 1 | 1080 | (0 -46 -26) to (20 -34 -14) centred at (8 -38 -19) | 6 -36 -20 | 0.011 | R anterior lobe, culmen |
| 16 -40 -16 | 0.010 | R anterior lobe, culmen | |||
| Cluster 2 | 560 | (-10 -48 -28) to (-2 -40 -18) centred at (-7 -44 -23) | -6 -44 -24 | 0.013 | L anterior lobe, culmen |
| PD | No clusters found | ||||
| PSP | |||||
| Cluster 1 | 976 | (-12 -42 -22) to (2 -32 -10) centred at (-6 -38 -16) | -6 -38 -16 | 0.014 | L anterior lobe, culmen |
| Cluster 2 | 912 | (-48 -58 -50) to (-42 -42 -42) centred at (-45 -49 -46) | -46 -46 -46 | 0.011 | L posterior lobe, tonsil |
| -46 -54 -46 | 0.010 | L posterior lobe, tonsil | |||
| Cluster 3 | 584 | (4 -54 -46) to (12 -46 -32) centred at (8 -50 -38) | 6 -48 -36 | 0.009 | R anterior lobe |
| 10 -52 -44 | 0.008 | R posterior lobe, tonsil |
AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; FTD, frontotemporal dementia; GM, grey matter; HD, Huntington’s disease; L, left; MNI, Montreal Neurological Institute; MSA, multisystem atrophy; PD, Parkinson’s disease; PSP, progressive supranuclear palsy; R, right.