Table 1

Statistically significant between-group and within-group grey matter volumetric associations in patients with functional neurological disorder and healthy controls

AnalysisMeasures of interestCerebral regions
(Brodmann area)
Peak coordinates in MNI Space (mm)Peak voxel
p Value
Cluster extent (mm3)
Between groupPoor physical health
13 FND <27 HC
L anterior insula (48)−4214−3−4.25<0.001 (0.007)342
Poor mental health
13 FND>27 HC
R cerebellum, crus I36−58−364.80<0.001 (0.036*)1453
Within groupImpaired mental health
positive associations
R amygdala (34)28−1−183.90<0.001 (0.004)415
STAI-Trait anxiety
positive associations
R amygdala (34)21−1−173.46<0.001 (0.018)132
Impaired emotional well-being
positive associations
R amygdala (34)27−1−183.54<0.001 (0.014)170
Role limitations due to emotional problems
positive associations
R amygdala (20)30−3−204.56<0.001 (<0.001)1018
Periaqueductal grey−3−37−124.12<0.001 (0.003)534
L amygdala/anterior hippocampus (20)−27−6−183.29<0.001 (0.030)596
Impaired physical functioning
negative associations
L anterior insula (48)−398−11−3.78<0.001 (0.039)179
  • Note: Physical and mental health are based on the two composite categories of the Short Form Health Survey-36 (SF-36). The ‘emotional well-being’, ‘role limitations due to emotional problems’, and ‘physical functioning’ measures are individual subscales of the SF-36. All SF-36 scores were inverted so that higher scores represent worse health status.

  • *Denotes whole-brain corrected p value.

  • FND, functional neurological disorder; HC, healthy controls; L, left; MNI, Montreal Neurological Institute; R, right; STAI-Trait Anxiety, Spielberger Trait Anxiety Inventory; SVC, small volume corrected.