Variable | CIS patients (n=86) |
Number (%) | |
| 28 (32.6) |
| 58 (67.4) |
Median age at onset (range) (years) | 31.0 (20–49) |
Median disease duration at baseline MRI (range) (months) | 2.4 (0.1–3.0) |
Median EDSS at baseline (range) | 1.5 (0.0–4.0) |
Clinical presenting symptom(s) (%): | |
Monofocal | 61 (70.9) |
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Multifocal | 25 (29.1) |
Number (%) of patients with oligoclonal bands | 60 (69.8) |
Baseline number (%) of patients with brain lesions | 82 (95.3) |
Median brain lesion number (range) | 19 (0–219) |
Baseline number (%) of patients with spinal cord lesions | 52 (60.5) |
Median spinal cord lesion number (range) | 1 (0–7) |
Baseline number (%) of patients with ≥1 PV lesion | 74 (86.0) |
Baseline number (%) of patients with ≥1 JC lesion | 72 (83.7) |
Baseline number (%) of patients with ≥1 PF lesion | 46 (53.5) |
Baseline number (%) of patients with ≥1 ICL | 45 (52.3) |
Median ICL lesion number (range) | 1 (0–10) |
Baseline number (%) of patients with ≥1 Gd(+) lesion | 28 (32.6) |
Median number of Gd(+) lesions (range) | 0 (0–23) |
CDMS at FU (%) | 57 (66.3) |
Median time to CDMS (range) (months) | 10.3 (1.0–62.0) |
Median MRI FU (range) (months) | 12.0 (3.0–12.1) |
Number (%) of patients with ≥1 new T2 lesion at FU MRI | 63 (73.3) |
Median number of new T2 lesions (range) | 3 (0–70) |
Number (%) of patients receiving treatment at FU | 36 (41.9) |
CDMS, clinically definite multiple sclerosis; CIS, clinically isolated syndrome; EDSS, Expanded Disability Status Scale; FU, follow-up; Gd, gadolinium; ICL, intracortical lesion; JC, juxtacortical; PF, posterior fossa; PV, periventricular.