Months −24 to −12
(second year before study)
Months −12 to 0
(year before study)
Months 0–8
(under treatment)
Change from second year before study to treatmentChange from year before study to treatment
  • P values are reported as results of Wilcoxon signed-rank test.

  • ARR, annualised relapse rate; EDSS, Expanded Disability Status Scale; FSS, Fatigue Severity Scale; HAQUAMS, Hamburg Quality of Life Questionnaire; PASAT, Paced Auditory Serial Addition Test; SDMT, Symbol Digit Modalities Test; SNRS, Scripps Neurological Rating Scale.