Performance of pNfH at fixed 95% sensitivity and specificity
| CSF pNfH | Serum pNfH | |||
| Disease controls | ALS mimics | Disease controls | ALS mimics | |
| 95% Sensitivity | 68.1% (60.9% to 74.6%) | 88.0% (68.8% to 97.5%) | 45.3% (38.5% to 52.2%) | 40.7% (22.4% to 61.2%) |
| 95% Specificity | 72.9% (62.2% to 82.0%) | 92.9% (85.3% to 97.4%) | 34.1% (24.2% to 45.2%) | 51.8% (40.7% to 62.7%) |
The specificity and sensitivity for each fixed 95% sensitivity and specificity level, respectively. Between brackets the 95% CI.
ALS, amyotrophic lateral sclerosis; CSF, cerebrospinal fluid; pNfH, phosphorylated neurofilament heavy chain.